Glenn T Konopaske, McLean Hospital, Belmont, Massachusetts, USA
David A Lewis, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Published online: September 2007
DOI: 10.1002/9780470015902.a0000062.pub2
Schizophrenia is a chronic psychiatric disorder characterized by psychotic symptoms and deterioration from previous levels of functioning; it may be a consequence of interactions between environmental factors and susceptibility genes. Treatment includes the combined use of antipsychotic medications and psychosocial therapy.
Keywords: schizophrenia; prefrontal cortex; dopamine; antipsychotic medication; psychiatry
| Further Reading | |
| book Cooper JR, Bloom FE and Roth RH (2002) The Biochemical Basis of Neuropharmacology, 8th edn. New York: Oxford University Press. | |
| Goff DC and Coyle JT (2001) The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. American Journal of Psychiatry 158: 1367–1377. | |
| Lewis DA and Gonzalez-Burgos G (2006) Pathophysiologically based treatment interventions in schizophrenia. Nature Medicine 12: 1016–1022. | |
| Mueser KT and McGurk SR (2004) Schizophrenia. The Lancet 363: 2063–2072. | |
| book Sadock BJ and Sadock VA (eds) (2000) Comprehensive Textbook of Psychiatry, 7th edn. Philadelphia, PA: Lippincott Williams and Wilkins. | |
| book Shatzberg AF and Nemeroff CB (eds) (2003) The American Psychiatric Publishing Textbook of Psychopharmacology, 3rd edn. Washington DC: American Psychiatric Publishing. | |
| book Spitzer M (1999) The Mind Within the Net: Models of Learning, Thinking, and Acting. Cambridge: Massachusetts Institute of Technology Press. | |
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