Neuronal Firing Pattern Modulation


Neurons generate diverse patterns of action potentials, depending on the intrinsic electrical properties of the neurons and on synaptic inputs from other neurons. The firing pattern of a neuron can be regulated, often by neurotransmitters acting via G proteinā€coupled receptors to modulate voltageā€dependent ion channels.

Keywords: action potential; bursting; adaptation; ion channel; neurotransmitter

Figure 1.

Schematic illustration of some possible neuronal firing patterns. Action potentials are simple vertical lines, and subthreshold changes in voltage are not shown. (a–d) Spontaneous activity, in the absence of inputs. Injection of hyperpolarizing current may cause an ‘anode break’ action potential (e) or burst (f). Depolarizing current can evoke a variety of responses (g–m).



Harris‐Warrick RM and Flamm RE (1986) Chemical modulation of a small central pattern generator. Trends in Neurosciences 9: 432–437.

Hodgkin AL and Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. Journal of Physiology 117: 500–544.

Jones SW and Adams PR (1987) The M‐current and other potassium currents of vertebrate neurons. In: Kaczmarek LK and Levitan IB (eds) Neuromodulation, pp. 159–186. New York: Oxford University Press.

Jones SW and Elmslie KS (1997) Transmitter modulation of neuronal calcium channels. Journal of Membrane Biology 155: 1–10.

Kauer JA, Fisher TE and Kaczmarek LK (1987) Alpha bag cell peptide directly modulates the excitability of the neurons that release it. Journal of Neuroscience 7: 3623–3632.

Levitan IB and Kaczmarek LK (1991) The Neuron. New York: Oxford University Press.

McCormick DA, Pape H‐C and Williamson A (1991) Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system. Progress in Brain Research 88: 293–305.

Madison DV and Nicoll RA (1986) Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro. Journal of Physiology 372: 245–259.

Nick TA, Kaczmarek LK and Carew TJ (1996) Ionic currents underlying developmental regulation of repetitive firing in Aplysia bag cell neurons. Journal of Neuroscience 16: 7583–7598.

Steriade M, McCormick DA and Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262: 679–685.

Further Reading

Benson JA and Adams WB (1987) The control of rhythmic neuronal firing. In: Kaczmarek LK and Levitan IB (eds) Neuromodulation, pp. 100–118. New York: Oxford University Press.

Hille B (1992) Ionic Channels of Excitable Membranes, 2nd edn. Sunderland, MA: Sinauer Associates.

Hille B (1994) Modulation of ion‐channel function by G‐protein‐coupled receptors. Trends in Neurosciences 17: 531–536.

Huguenard JR (1996) Low‐threshold calcium currents in central nervous system neurons. Annual Review of Physiology 58: 329–348.

Kramer RH, Levitan ES, Carrow GM and Levitan IB (1988) Modulation of a subthreshold calcium current by the neuropeptide FMRFamide in Aplysia neuron R15. Journal of Neurophysiology 60: 1728–1738.

Levitan ES, Kramer RH and Levitan IB (1987) Augmentation of bursting pacemaker activity by egg‐laying hormone in Aplysia neuron R15 is mediated by a cyclic AMP‐dependent increase in Ca2+ and K+ currents. Proceedings of the National Academy of Sciences of the USA 84: 6307–6311.

Loechner KJ and Kaczmarek LK (1989) Regulation of ion channels in Aplysia neurons by autoactive peptides and second messengers. Society of General Physiologists Series 44: 69–82.

Steriade M (1993) Cholinergic blockage of network‐ and intrinsically generated slow oscillations promotes waking and REM sleep activity patterns in thalamic and cortical neurons. Progress in Brain Research 98: 345–355.

Strong JA and Kaczmarek LK (1987) Potassium currents that regulate action potentials and repetitive firing. In: Kaczmarek LK and Levitan IB (eds) Neuromodulation, pp. 119–137. New York: Oxford University Press.

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Jones, Stephen W(Apr 2001) Neuronal Firing Pattern Modulation. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0000174]