Marie‐Francoise Chesselet, University of California Los Angeles, School of Medicine, Los Angeles, California, USA
Terry Reisine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Published online: April 2001
DOI: 10.1038/npg.els.0000179
Somatostatin is a neuropeptide, originally isolated from the hypothalamus as an inhibitor of growth hormone secretion. In addition to the regulation of growth hormone release, this neurohormone is involved in the regulation of insulin and glucagon secretion, neurotransmitter release and complex behaviours such as locomotion and cognition.
Keywords: neuropeptide; G protein-linked receptor; growth hormone; signal transduction; basal ganglia; desensitization
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| Further Reading | |
| Epelbaum J (1986) Somatostatin in the central nervous system: physiology and pathological modifications. Progress in Neurobiology 27: 63–100. | |
| Hoyer D, Bell GI, Berelowitz M et al. (1995) Classification and nomenclature of somatostatin receptors. Trends in Pharmacological Science 16: 86–88. | |
| book Lamberts S, de Herder W, van Koetsveld P et al. (1995) "Somatostatin receptors: clinical implications for endocrinology and oncology". Somatostatin and Its Receptors, pp. 222–239. New York: Wiley and Ciba Foundation. | |
| Montminy M, Brindle P, Arias J, Ferreri K and Armstrong R (1996) Regulation of somatostatin gene transcription by cAMP. Advances in Pharmacology 36: 1–13. | |
| Reichlin S (1983) Somatostatin. New England Journal of Medicine 309: 1495–1501, 1556–1563. | |
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