Somatostatin is a neuropeptide, originally isolated from the hypothalamus as an inhibitor of growth hormone secretion. In addition to the regulation of growth hormone release, this neurohormone is involved in the regulation of insulin and glucagon secretion, neurotransmitter release and complex behaviours such as locomotion and cognition.

Keywords: neuropeptide; G protein‐linked receptor; growth hormone; signal transduction; basal ganglia; desensitization


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Chesselet, Marie‐Francoise, and Reisine, Terry(Apr 2001) Somatostatin. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0000179]