Somatostatin

Abstract

Somatostatin is a neuropeptide, originally isolated from the hypothalamus as an inhibitor of growth hormone secretion. In addition to the regulation of growth hormone release, this neurohormone is involved in the regulation of insulin and glucagon secretion, neurotransmitter release and complex behaviours such as locomotion and cognition.

Keywords: neuropeptide; G protein‐linked receptor; growth hormone; signal transduction; basal ganglia; desensitization

References

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Further Reading

Epelbaum J (1986) Somatostatin in the central nervous system: physiology and pathological modifications. Progress in Neurobiology 27: 63–100.

Hoyer D, Bell GI, Berelowitz M et al. (1995) Classification and nomenclature of somatostatin receptors. Trends in Pharmacological Science 16: 86–88.

Lamberts S, de Herder W, van Koetsveld P et al. (1995) Somatostatin receptors: clinical implications for endocrinology and oncology. Somatostatin and Its Receptors, pp. 222–239. New York: Wiley and Ciba Foundation.

Montminy M, Brindle P, Arias J, Ferreri K and Armstrong R (1996) Regulation of somatostatin gene transcription by cAMP. Advances in Pharmacology 36: 1–13.

Reichlin S (1983) Somatostatin. New England Journal of Medicine 309: 1495–1501, 1556–1563.

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How to Cite close
Chesselet, Marie‐Francoise, and Reisine, Terry(Apr 2001) Somatostatin. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000179]