GABAB Receptors

Klemens Kaupmann, Novartis Pharma AG, Basel, Switzerland
Wolfgang Froestl, Novartis Pharma AG, Basel, Switzerland
Bernhard Bettler, Novartis Pharma AG, Basel, Switzerland

Published online: April 2001

DOI: 10.1038/npg.els.0000234

-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/C) and metabotropic (GABAB) receptor systems. GABAB receptors modulate synaptic transmission and are structurally related to the metabotropic glutamate receptors. The properties of the recently cloned GABABR1a and -b receptors are compared to brain GABAB receptors.

Keywords: baclofen; expression cloning; metabotropic; mGluR; G-protein; epilepsy

Figure 1. Structural model of GABAB receptors. The putative GABA-binding site is located in the extracellular domain. GABABR1a and -b are N-terminal splice variants derived from the same gene. The N-terminal 147 amino acids of the mature GABABR1a are replaced by 18 different residues in GABABR1b. The putative GABA-binding site located in the extracellular N-terminal domain is identical in the two splice variants.
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 Further Reading
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Related Sub-Topics:

Ion Channels | Receptors for Neurotransmitters | Membrane Proteins
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Article Title: GABAB Receptors
 
How to Cite close
Kaupmann, Klemens, Froestl, Wolfgang, and Bettler, Bernhard(Apr 2001) GABAB Receptors. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000234]