Neurotransmitters are released into the extracellular space during synaptic transmission. The actions of these chemical signals are terminated through active uptake by transporters that are located in the plasma membrane of neurons and glial cells. Transporters harness electrochemical gradients to force the movement of transmitter back into cells against its concentration radient. These proteins play an important role in determining how long chemical signals persist, and as a result drugs that inhibit transporters produce profound behavioural effects.
Keywords: uptake; synapse; transmitter; diffusion; glutamate