Fungal Cells

Fungal cells have been used to produce a variety of useful items such as bread, beer, cheese and antibiotics. The study of fungal cells has also facilitated advances in medicine and agriculture.

Keywords: one gene–one enzyme hypothesis; uniparental gene transmission; gene transfer system; yeast two hybrid system; ribonucleic acid (RNA) silencing and proteomics

 Further Reading
    book Allen MF (1992) Mycorrhizal Functioning: An Integrative Plant-Fungal Process. New York, NY: Chapman and Hall.
    Fire A (1999) RNA triggered silencing. Trends in Genetics 15: 358–363.
    Beadle GW and Tatum EL (1941) Genetic control of biochemical reaction in Neurospora. Proceedings of the National Academy of Sciences of the USA 27: 499–506.
    Cogini C, Irelan JT, Schumacher M et al. (1996) Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNADNA interaction or DNA methylation. EMBO Journal 15: 3153–3163.
    Fire A, Xu S, Montegomery MK et al. (1998) Potent and specific genetic interference by double-stranded RNA in C. elegans. Nature 391: 806–811.
    Gavin AC, Bösche M, Krause R et al. (2002) Functional organization of the yeast proteome by systemic analysis of protein complex. Nature 415: 141–147.
    Goffeau A, Barrell BG, Bussey H et al. (1996) Life with 6000 genes. Science 274: 546–567.
    Hamilton A and Baulcombe D (1999) A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286(5441): 950–952.
    other Hamlyn PF (1998) Fungal biotechnology. British Mycological Society News Letter, May 1–6.
    Ho Y, Gruhler A, Heilbut A et al. (2002) Systematic identification of protein complexes in S. cerevisiae. Nature 415: 180–183.
    Kupfer DM, Reece CA, Clifton SW, Roe BA and Prade RA (1997) Multicellular ascomycetous genomes contain more than 8000 genes. Fungal Genetics and Biology 21: 364–372.
    Lyris MF, Olsen JV, de Souza GA et al. (2006) Status of complete proteome analysis by mass spectrometry SILAC labelled yeast as a model system. Genome Biology 7: R50–R66.
    Mishra NC (1985) Gene transfer in fungi. Advances in Genetics 23: 73–177.
    Mishra NC and Tatum EL (1973) Non-Mendelian inheritance of DNA-induced inositol independence in Neurospora. Proceedings of the National Academy of Sciences of the USA 70: 3875–3879.
    Mitchell AP (1998) Dimorphism and virulence in Candida albicans. Current Opinion in Microbiology 6: 687–692.
    Montgomery MK and Fire A (1998) Double stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression. Trends in Genetics 14: 225–256.
    Napoli C, Lemieux C and Jorgensen R (1990) Introduction of a chimeric chalcone synthase gene into petunia results in irreversible cosuppression of homologous gene in trans. Plant Cell 2: 279–289.
    Romano N and Macino G (1992) Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Molecular Microbiology 6: 3343–3353.
    Ruvkun G (2001) Molecular biology: glimpses of a tiny RNA world. Science 294: 797–799.
    Tong AH, Drees B, Nardeli G et al. (2002) A combined experimental and computational strategy to define protein interaction networks for peptide recognition module. Science 295: 321–324.
    Zhang B, Salituro G, Szalkowski D et al. (1999) Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science 284: 794–797.
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Mishra, Nawin C(Dec 2007) Fungal Cells. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0000354.pub2]