Haemorrhagic Fever Viruses

Abstract

Viral haemorrhagic fever is a clinical definition for several diseases. They are due to viruses that belong to different families and are transmitted in different ways.

Keywords: infectious diseases; virology; septic shock; ecology

Figure 1.

Hypothetical mechanism of intravascular coagulation and shock induced by the haemorrhagic fever viruses. Viruses in the bloodstream may infect macrophages and endothelial cells. Stimulated cells produce tumour necrosis factor α (TNFα) and interleukin 6 (IL‐6), known to induce capillary permeability. These molecules trigger the production of other cytokines, leading to the systemic inflammatory response syndrome. The endothelial cells are not destroyed by viral infection; however, their membrane is modified and favours the aggregation of platelets, leading to disseminated intravascular coagulation (DIC) and haemorrhages.

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References

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Further Reading

Cosgriff T (ed.) (1989) Proceedings of the International Symposium on Hemostatic Impairment Associated with Hemorrhagic Fever Viruses. Reviews of Infectious Diseases 11 (supplement 4).

Fischer‐Hoch S and McCormick J (1990) Pathogenesis of haemorrhagic fevers. In: Zuckerman A, Banatvala J and Pattison J (eds) Principles and Practice of Clinical Virology, pp. 475–491. Chichester, UK: Wiley.

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Le Guenno, Bernard(Apr 2001) Haemorrhagic Fever Viruses. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000414]