Haemorrhagic Fever Viruses


Viral haemorrhagic fever is a clinical definition for several diseases. They are due to viruses that belong to different families and are transmitted in different ways.

Keywords: infectious diseases; virology; septic shock; ecology

Figure 1.

Hypothetical mechanism of intravascular coagulation and shock induced by the haemorrhagic fever viruses. Viruses in the bloodstream may infect macrophages and endothelial cells. Stimulated cells produce tumour necrosis factor α (TNFα) and interleukin 6 (IL‐6), known to induce capillary permeability. These molecules trigger the production of other cytokines, leading to the systemic inflammatory response syndrome. The endothelial cells are not destroyed by viral infection; however, their membrane is modified and favours the aggregation of platelets, leading to disseminated intravascular coagulation (DIC) and haemorrhages.



Bowen M, Peters C and Nichol S (1997) Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts. Molecular Phylogenetics and Evolution 8(3): 301–316.

Feldmann H and Klenk H (1996) Marburg and Ebola viruses. Advances in Virus Research 47: 1–52.

Feldmann H, Bugany H, Mahner F et al. (1996) Filovirus‐induced endothelial leakage triggered by infected monocytes/macrophages. Journal of Virology 70: 2208–2214.

Gubler D and Clark G (1995) Dengue/dengue hemorrhagic fever: the emergence of a global health problem. Emerging Infectious Diseases 1(2): 55–57.

Hoogstraal H (1979) The epidemiology of tick‐borne Crimean–Congo hemorrhagic fever in Asia, Europe and Africa. Journal of Medical Entomology 15: 307–417.

Le Guenno B and Galabru J (1997) Ebola virus. Bulletin de l'Institut Pasteur 95: 73–83.

Lewis R, Morrill J, Jahrling P and Cosgriff T (1989) Replication of hemorrhagic fever viruses in monocytic cells. Reviews of Infectious Diseases 11 (supplement 4): S736–742.

Monath T (1988) Yellow fever. In: Monath T (ed.) The Arboviruses, Epidemiology and Ecology, pp. 139–231. Boca Raton, FL: CRC Press.

Reinhart K, Wiegand‐Lohnert C, Grimminger F et al. (1996) Assessment of the safety and efficacy of the monoclonal anti‐tumor necrosis factor antibody‐fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo‐controlled, dose‐ranging study. Critical Care Medicine 24(5): 733–742.

Schmaljohn C and Hjelle B (1997) Hantaviruses: a global disease problem. Emerging Infectious Diseases 3: 95–104.

Further Reading

Cosgriff T (ed.) (1989) Proceedings of the International Symposium on Hemostatic Impairment Associated with Hemorrhagic Fever Viruses. Reviews of Infectious Diseases 11 (supplement 4).

Fischer‐Hoch S and McCormick J (1990) Pathogenesis of haemorrhagic fevers. In: Zuckerman A, Banatvala J and Pattison J (eds) Principles and Practice of Clinical Virology, pp. 475–491. Chichester, UK: Wiley.

Le Guenno B (1995) Emerging viruses. Scientific American 273(4): 56–64.

Le Guenno B (1997) Hemorrhagic fevers and ecological perturbations. Archives of Virology Supplementum 13: 191–199.

Martini G and Siegert R (eds) (1971) Marburg Virus Disease. Berlin: Springer‐Verlag.

Monath T (ed.) (1988) The Arboviruses, Epidemiology and Ecology (5 volumes). Boca Raton, FL: CRC Press.

Pattyn S (ed.) (1978) Ebola Virus Haemorrhagic Fever. Amsterdam: Elsevier/North Holland.

Porterfield J (ed.) (1995) Exotic Viral Infections. Oxford: Chapman and Hall.

Schwarz T and Siegl G (eds) (1996) Proceedings of the Symposium on Imported Virus Infection. Archives of Virology. Supplementum 11.

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Le Guenno, Bernard(Apr 2001) Haemorrhagic Fever Viruses. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000414]