Virus Structure

Viruses are infectious obligate intracellular parasites consisting of RNA or DNA in a protective coat. They cannot increase in size but can replicate in susceptible host cells, which may or may not be destroyed by viral replication and release.

Keywords: capsid; icosahedral symmetry; helical symmetry; tailed phage; enveloped virus

Figure 1. Some viruses and their families: size and morphology. (a) Vaccinia virus (Poxviridae); (b) Rabies virus (Rhabdoviridae); (c) Mumps virus (Paramyxoviridae); (d) T-even viruses (Myoviridae); (e) Coliphage (Siphoviridae); (f) Herpes simplex virus (Herpesviridae); (g) Human adenovirus 2 (Adenoviridae); (h) Human immunodeficiency virus (Retroviridae); (i) Influenza virus (Orthomyxoviridae); (j) Tobacco mosaic virus (Tobamovirus); (k) Simian virus 40 (Papovaviridae); (l) Rhinovirus (Picornaviridae); (m) Maize streak virus (Geminiviridae); (n) Coliphage X174 (Microviridae); (o) Canine parvovirus (Parvoviridae).
Figure 2. (a) Icosahedral symmetry. (b) Helical symmetry. , subunits per helical turn; P, pitch of helix; p, axial rise per subunit.
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 References
    Baltimore D (1976) Viruses, polymerases and cancer. Science 192: 632–636.
    Butler PJG, Finch JL and Zimmern D (1977) Configuration of tobacco mosaic virus RNA during virus assembly. Nature 265: 217–219.
    Caspar D and Klug A (1962) Physical principles in the construction of regular viruses. Cold Spring Harbor Symposium on Quantitative Biology 27: 1–24.
    book Chiu W, Roger MB and Garcea RL (eds) (1997) Structural Biology of Viruses. New York: Oxford University Press.
    book Fields BN and Knipe DM (eds) (1998) Virology, 4th edn, vols 1 and 2. New York: Raven Press.
    Grimes JM, Burroughs JN, Gouet P et al. (1998) The atomic structure of the bluetongue virus core. Nature 395: 470–478.
    Harrison SC, Olson A, Schutt CE, Winkler FK and Bricogne G (1978) Tomato stunt virus at 2.9 Å resolution. Nature 276: 368–373.
    Liljas L, Unge T, Jones A et al. (1982) Structure of satellite Tobacco necrosis virus at 3.0 Å resolution. Journal of Molecular Biology 159: 93–108.
    Liu DT and Day LA (1994) Pf1 virus structure: helical coat protein and DNA with paraxial phosphates. Science 265: 671–674.
    Riesner D and Gross HJ (1985) Viroids. Annual Review of Biochemistry 54: 531–564.
    Rossmann MG (1998) From the structure of simple salts to those of sophisticated viruses. Acta Crystallographica A 54: 716–728.
    Turner BG and Summers MF (1999) Structural biology of HIV. Journal of Molecular Biology 285: 1–32.
 Further Reading
    book Cann AJ (1993) Principles of Molecular Virology. New York: Academic Press.
    book Chiu W, Roger MB and Garcea RL (1997) Structural Biology of Viruses. New York: Oxford University Press.
    book Dimmock NJ and Primrose SB (1994) Introduction to Modern Virology, 4th edn. Oxford: Blackwell Scientific.
    book Fields BN and Knipe DM (1998) Virology, 4th edn, vols 1 and 2. New York: Raven Press.
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McKenna, Robert, and Faulkner, Lee(Apr 2001) Virus Structure. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000439]