Immune Defence: Role of Reactive Nitrogen Intermediates

David A Wink, National Institutes of Health, Bethesda, Maryland, USA
Deborah Citrin, National Institutes of Health, Bethesda, Maryland, USA
Michael P Vitek, Duke University Medical Center, Durham, North Carolina, USA
Carol Colton, Duke University Medical Center, Durham, North Carolina, USA
Roberto Pacelli, National Institutes of Health, Bethesda, Maryland, USA
Rygeio Ogawa, National Institutes of Health, Bethesda, Maryland, USA
Douglas D Thomas, National Institutes of Health, Bethesda, Maryland, USA
Katrina M Miranda, National Institutes of Health, Bethesda, Maryland, USA
Michael G Espey, National Institutes of Health, Bethesda, Maryland, USA

Published online: May 2002

DOI: 10.1038/npg.els.0000484

An exploration of the different facets of the NO redox chemistry in the immune response to different pathogens.

Keywords: nitric oxide; oxidative and nitrosative stress; immune response

Figure 1. Chemical biology of nitric oxide. This scheme represents the basic reactions that nitric oxide undergoes in biological systems. At low concentrations, reactions where NO reacts directly with its substrate are referred to as ′direct effects′. Indirect effects result from the reaction of NO with either oxygen or superoxide to produce intermediates that mediate either oxidative or nitrosative stress.
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 References
    Green LC, Ruiz de Luzuriaga K, Wagner DA, et al. (1981) Nitrate biosynthesis in man. Proceedings of the National Academy of Sciences of the USA 78: 7764–7768.
    Hibbs JB, Vavrin Z and Taintor RR (1987) L‐arginine is required for the expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. Journal of Immunology 138: 550–565.
    Lancaster JR and Hibbs JB (1990) EPR demonstration of iron–nitrosyl complex formation by cytotoxic activated macrophages. Proceedings of the National Academy of Sciences of the USA 87: 1223–1227.
    Stuehr DJ and Marletta MA (1985) Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proceedings of the National Academy of Sciences of the USA 82: 7738–7742
    Wink DA and Mitchell JB (1998) The chemical biology of nitric oxide: insights into regulatory, cytotoxic and cytoprotective mechanisms of nitric oxide. Free Radical Biology and Medicine 25: 434–456.
 Further Reading
    Ambs S, Bennett WP, Merriam WG et al. (1999) Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. Journal of the National Cancer Institute 91: 86–88.
    book Anstey NM, Wienberg JB and Granger DL (1999) "Nitric oxide in malaria". In: Fang F (ed.) Nitric Oxide and Infection, pp. 311–342. New York: Kluwer Publishing/Plenum Press.
    book Bogdan C, Rollington M and Diefenbach A (1999) "Nitric oxide in leishmaniasis: from antimicrobial to immunoregulation". In: Fang F (ed.) Nitric Oxide and Infection, pp. 361–378. New York: Kluwer Publishing/Plenum Press.
    book Chan J and Flynn J (1999) "Nitric oxide in Mycobacterium tuberculosis". In: Fang F (ed.) Nitric Oxide and Infection, pp. 281–310. New York: Kluwer Publishing/Plenum Press.
    Croen KD (1993) Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. Journal of Clinical Investigation 91: 2446–2452.
    Dawson VL, Dawson TM, Uhl GR and Snyder SH (1993) Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proceedings of the National Academy of Sciences of the USA 90: 3256–3259.
    Fang FC (1997) Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide‐related antimicrobial activity. Journal of Clinical Investigation 99: 2818–2825.
    Fridovich I (1997) Superoxide anion radical (math), superoxide dismutases, and related matters. Journal of Biological Chemistry 272: 18515–18517.
    Granger DL and Hibbs JBJ (1996) High‐output nitric oxide: weapon against infection? Trends in Microbiology 4: 46–47.
    book Halliwell B and Gutteridge JMC (1989) "Enzymatic and nonenzymatic lipid peroxidation". In: Halliwell B and Gutteridge JMC (eds) Free Radicals in Biology and Medicine, pp. 210–211. Oxford, UK: Clarendon Press.
    Hori K, Burd PR, Furuke K et al. (1999) Human immunodeficiency virus‐1‐infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome. Blood 93: 1843–1850.
    Karupiah G, Chen JH, Mahalingam S, Nathan CF and MacMicking JD (1998) Rapid interferon gamma‐dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2‐deficient mice. Journal of Experimental Medicine 188: 1541–1546.
    Klebanoff SJ (1993) Reactive nitrogen intermediates and antimicrobial activity: role of nitrite. Free Radicals in Biology and Medicine 14: 351–360.
    Nathan C and Shiloh MU (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proceedings of the National Academy of Sciences of the USA 97: 8841–8848.
    Nathan C and Xie Q (1994) Regulation of biosynthesis of nitric oxide. Journal of Biological Chemistry 269: 13725–13728.
    Ogawa R, Pacelli R, Espey MG et al. (2000) Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors. Insights into listeriocidal activity of oxidative and nitrosative stress. Free Radicals in Biology and Medicine 30: 268–276.
    book Oswald IP (1999) "Nitric oxide in schistosomiasis". In: Fang F (ed.) Nitric Oxide and Infection, pp. 343–360. New York: Kluwer Publishing/Plenum Press.
    Pacelli R, Wink DA, Cook JA et al. (1995) Nitric oxide potentiates hydrogen peroxide‐induced killing of Escherichia coli. Journal of Experimental Medicine 182: 1469–1479.
    Snell JC, Chernyshev O, Gilbert DL and Colton CA (1997) Polyribonucleotides induce nitric oxide production by human monocyte‐derived macrophages. Journal of Leukocyte Biology 62: 369–373.
    Stuehr DJ (1997) Structure–function aspects in the nitric oxide synthases. Annual Review of Pharmacology and Toxicology 37: 339–359.
    book Wienberg JB (1999) "Human mononuclear phagocyte nitric oxide production and inducible nitric oxide synthase". In: Fang F (ed.) Nitric Oxide and Infection, pp. 95–150. New York: Kluwer Publishing/Plenum Press.
    Wink DA, Vodovotz Y, Laval J et al. (1998) The multifaceted roles of nitric oxide in cancer. Carcinogenesis 19: 711–721.
    Wink DA, Vodovotz Y, Grisham MB et al. (1999) Antioxidant effects of nitric oxide. Methods in Enzymology 301: 413–424.
    Wink DA, Miranda KM, Grisham MB et al. (2001) Mechanisms of the antioxidant effects of nitric oxide. Antioxidant Redox Signal 3: 203–213.
    Xie K and Fidler IJ (1998) Therapy of cancer metastasis by activation of the inducible nitric oxide synthase. Cancer Metastasis Review 17: 55–75.

Related Sub-Topics:

Infection | Immunoregulation | Inflammation | Innate Immunity
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Article Title: Immune Defence: Role of Reactive Nitrogen Intermediates
 
How to Cite close
Wink, David A, Citrin, Deborah, Vitek, Michael P, Colton, Carol, Pacelli, Roberto, Ogawa, Rygeio, Thomas, Douglas D, Miranda, Katrina M, and Espey, Michael G(May 2002) Immune Defence: Role of Reactive Nitrogen Intermediates. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000484]