Immune Response: Evasion and Subversion by Pathogens

Geneviève Milon, Institut Pasteur, Paris, France
Peter David, Institut Pasteur, Paris, France

Published online: May 2005

DOI: 10.1038/npg.els.0000485

Pathogenic microorganisms may evade rapid clearance by effectors of the immune system of the hosts they encounter, or they may subvert the regulatory pathways of the immune system of the hosts. These two processes are essential for microorganisms' fitness, transmissibility and perpetuation, the very essence of host-dependent/parasitic microorganisms.

Keywords: parasitism; life-cycle; microorganism transmission; immunogenicity

 References
    Belkaid Y, Piccirillo CA, Mendez S, Shevach EM and Sacks D (2002) CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420: 502–507.
    Damian RT (1997) Parasite immune evasion and exploitation: reflections and projections. Parasitology 115: S169–S175.
    Ferguson DJ (2004) Use of molecular and ultrastructural markers to evaluate stage conversion of Toxoplasma gondii in both the intermediate and definitive host. International Journal of Parasitology 34: 347–360.
    Frischknecht F, Baldacci P, Martin B et al. (2004) Imaging movement of malaria parasites during transmission by Anopheles mosquitoes. Cellular Microbiology 7: 687–694.
    Mendez S, Reckling SK, Piccirillo CA, Sacks D and Belkaid Y (2004) Role for CD4+ CD25+ Regulatory T cells in reactivation of persistent Leishmaniasis and control of concomitant immunity. Journal of Experimental Medicine 19: 201–210.
    Mukhopadhyay S, Herre J, Brown G and Gordon S (2004) The potential for Toll-like receptors to collaborate with other innate immune receptors. Immunology 112: 521–530.
    Sibley LD (2004) Intracellular parasite invasion strategies. Science 304: 248–253.
    Smith H (2000) Questions about the behaviour of bacterial pathogens in vivo. Philosophical Transactions of the Royal Society of London B 355: 551–564.
    Tschopp J, Martinon F and Burns K (2003) NALPS: a novel protein family involved in inflammation. Nature Reviews/Molecular Cell Biology 4: 95–104.
    Yoo JY and Desiderio S (2003) Innate and acquired immunity intersect in a global view of the acute-phase response. Proceedings of the National Academy of Sciences of the USA 100: 1157–1162.
 Further Reading
    Beverley SM (1996) Hijacking the cell: parasites in the driver's seat. Cell 87: 787–789.
    Blocker A, Komoriya K and Aizawa S-I (2003) Type III secretion systems and bacterial flagella: insights into their function from structural similarities. Proceedings of the National Academy of Sciences of the USA 100: 3027–3030.
    Combes C (1997) Fitness of parasites: pathology and selection. International Journal of Parasitology 27: 1–10.
    Cyster JG (2003) Homing of antibody-secreting cells. Immunological Reviews 194: 48–60.
    book Doenhoff MJ and Chappell LH (eds.) (1997) "Survival of parasites, microbes and tumours: strategies for evasion, manipulation and exploitation of the immune response". Parasitology 115: S1–S175.
    Ernst JD (2000) Bacterial inhibition of phagocytosis. Cellular Microbiology 2: 379–386.
    Falkow S (1997) What is a pathogen? ASM News 63: 359–365.
    Finlay BB and Falkow S (1997) Common themes in microbial pathogenicity revisited. Microbiology and Molecular Biology Reviews 61: 136–139.
    Hall R (1994) Molecular mimicry. Advances in Parasitology 34: 81–132.
    Hansen DS, Siomos M-A, de Koning-Ward T et al. (2003) CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses. European Journal of Immunology 33: 2588–2598.
    Hornef MW, Wick MJ, Rhen M and Normark S (2002) Bacterial strategies for overcoming host innate and adaptive immune responses. Nature Immunology 3: 1033–1040.
    Knodler LA, Celli J and Finlay BB (2001) Pathogenic trickery: deception of host cell processes. Nature Reviews Immunology 2: 578–588.
    Lasa I, Dehoux P and Cossart P (1998) Actin polymerization and bacterial movement. Biochimica et Biophysica Acta 1402: 217–228.
    Lipsitch M and Moxon ER (1997) Virulence and transmissibility of pathogens: what is the relationship? Trends in Microbiology 5: 31–37.
    Liston A and McColl S (2003) Subversion of the chemokine world by microbial pathogens. BioEssays 25: 478–488.
    Mann BJ (2002) Structure and function of the Entamoeba histolytica Gal/GalNAc lectin. International Review of Cytology 216: 59–80.
    Pays E and Donelson J (1998) Special issue. The trypanosome surface. Molecular and Biochemical Parasitology 91: 1–205.
    Petri WA Jr, Haque R and Mann BJ (2002) The bittersweet interface of parasite and host: lectin–carbohydrate interactions during human invasion by the parasite Entamoeba histolytica. Annual Review of Microbiology 56: 39–64.
    Pirofski L-A and Casadevall A (2002) The meaning of microbial exposure, infection, colonisation, and disease in clinical practice. The Lancet Infectious Diseases 2: 628–635.
    Rosenberger CM and Finlay BB (2003) Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens. Nature Reviews Molecular Cell Biology 4: 385–396.
    Sacks D and Sher A (2002) Evasion of innate immunity by parasitic protozoa. Nature Immunology 3: 1041–1047.
    Ward GE, Chitnis CE and Miller LH (1994) The invasion of erythrocytes by malarial merozoites. In: Baillière's Clinical Infectious Disease 1: 155–190.
    Young D, Hussell T and Dougan G (2002) Chronic bacterial infections: living with unwanted guests. Nature Immunology 3: 1026–1032.

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Infection | Immunoregulation
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Article Title: Immune Response: Evasion and Subversion by Pathogens
 
How to Cite close
Milon, Geneviève, and David, Peter(May 2005) Immune Response: Evasion and Subversion by Pathogens. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000485]