Vaccines: Subunit

Abstract

Subunit vaccines, both purified native components of pathogens and vaccines developed and produced by recombinant techniques, are now dominating in the strive for an ideal vaccine. Subunit vaccines are highly attractive alternatives to the classical vaccines consisting of live attenuated or killed whole bacteria or viruses.

Keywords: vaccine development; recombinant; protein vaccine; surface display; live bacteria; viral vector; DNA vaccine; RNA vaccine

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Further Reading

Holmgren J, Lycke N and Czerkinsky C (1993) Cholera toxin and cholera toxin B subunit as oral‐mucosal adjuvant and antigen vector systems. Vaccine 11: 1179–1184.

McGhee JR, Mestecky J, Dertzbaugh MT et al. (1992) The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10: 75–88.

Paoletti E (1996) Applications of pox virus vectors to vaccination: an update. Proceedings of the National Academy of Sciences of the USA 93: 11349–11353.

Plotkin SA (1993) Vaccination in the 21st century. Journal of Infectious Diseases 168: 29–37.

Ståhl S, Samuelson S, Hansson M et al. (1997) Development of non‐pathogenic staphylococci as vaccine delivery vehicles. In: Wells J and Pozzi G (eds) Recombinant Gram‐positive Bacteria as Vaccine Vehicles for Mucosal Immunization, pp. 61–81. New York: RG Landes Biomedical.

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How to Cite close
Ståhl, Stefan, and Liljeqvist, Sissela(Apr 2001) Vaccines: Subunit. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000490]