Vaccines: Whole Organism

Abstract

Vaccines are designed to protect people or animals against the clinical symptoms associated with infection by particular pathogenic agents. They are composed of antigens, derived from pathogens, that can be presented to the immune system in order to induce a protective immune response.

Keywords: Immune response; protective antigens; reactogenicity; endotoxins; vaccinology; whooping cough

References

Dougan G (1994) The molecular basis for the virulence of bacterial pathogens: implications for oral vaccine development. Colworth Lecture. Microbiology 140: 215–224.

Klugman KP, Koornhof HJ, Robbins JB and Le Cam NN (1996) Immunogenicity, efficacy and serological correlate of protection of Salmonella typhi Vi capsular polysaccharide vaccine three years after immunisation. Vaccine 14: 435–438.

Kurstak M (1994) Modern Vaccinology. New York: Plenum Publishing.

Levine MM, Woodrow GC, Kaper JB and Cobon GS (1997) New Generation Vaccines, 2nd edn. New York: Marcel Dekker.

Rappuoli R (1997) Rational design of vaccines. Nature Medicine 3: 374–376.

Further Reading

Jordon W (1998) The Jordon Report: Accelerated Development of Vaccines 98. Bethesda: National Institutes of Health.

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How to Cite close
Dougan, Gordon(Apr 2001) Vaccines: Whole Organism. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000491]