Ribosomal Proteins in Eukaryotes

Abstract

About 80 different ribosomal proteins are involved in the biogenesis and functioning of eukaryotic ribosomes. Genome sequencing efforts have contributed to our knowledge on their evolution, and recent progress in the structural analysis of the ribosome has considerably improved our understanding of the localization and function of individual ribosomal proteins, some of which are also involved in extraribosomal functions.

Keywords: eukaryotic ribosomal proteins; evolution; localization; function; genes

Figure 1.

The mammalian 40S ribosomal subunit model obtained by immuno‐electron microscopy in four different positions, showing (a) the location of ribosomal proteins S2, S3, S3A, S5, S7, S9, S13, S17, S19, S21 and S24, and (b) the location of initiation factors eIF2 and eIF3 with mRNA and Met‐tRNA (bound to eIF2) at the surface of the 40S ribosomal subunit. Views (top to bottom) are on the concave frontal side, the external side, the convex rear side and the interface side. Reproduced with permission from Lutsch et al. (1990), Copyright 1990, Gustav Fischer Verlag.

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The Ribosome (2001). Cold Spring Harbor Symposia on Quantitative Biology, Vol. LXVI.

Wool IG (1996) Extraribosomal functions of ribosomal proteins. Trends in Biochemical Sciences 21: 164–165.

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Bommer, Ulrich‐Axel, and Stahl, Joachim(Jan 2006) Ribosomal Proteins in Eukaryotes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003867]