Proteins: Postsynthetic Modification – Function and Physical Analysis

Abstract

Analysis of the entire genome (genomics) provides static information about the genes of an organism. In contrast, total protein analysis (proteomics) reflects the dynamic situation, providing information about the rate of expression and regulation of individual proteins within the cell. Clues as to the function of proteins in diverse cell processes can only be obtained if their structure and modifications or variations are fully understood. Recently, we learned to define important individual posttranslational protein modifications for function.

Keywords: protein modifications; structure and function of modifications; identification of modifications; 2DE separation and MS analysis; protein processing; phosphorylation

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Wittmann‐Liebold, Brigitte, and Choli‐Papadopoulou, Theodora(Sep 2007) Proteins: Postsynthetic Modification – Function and Physical Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0000551.pub2]