Genetic analysis in the small nematode worm Caenorhabditis elegans has elucidated the mechanisms of many basic biological processes.
Keywords: genetics; development; cell lineage; nematode
Andrew Chisholm, University of California, Santa Cruz, California, USA
Yishi Jin, University of California, Santa Cruz, California, USA
Published online: March 2003
DOI: 10.1038/npg.els.0000564
Genetic analysis in the small nematode worm Caenorhabditis elegans has elucidated the mechanisms of many basic biological processes.
Keywords: genetics; development; cell lineage; nematode
| References | |
| Bargmann CI, Hartwieg E and Horvitz HR (1993) Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell 74: 515527. | |
| C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282: 20122018. | |
| Chervitz SA, Aravind L, Sherlock G et al. (1998) Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science 282: 20222028. | |
| de Bono M and Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behaviour and food response in C. elegans. Cell 94: 679689. | |
| Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806811. | |
| Goodman MB, Hall DH, Avery L and Lockery SR (1998) Active currents regulate sensitivity and dynamic range in C. elegans neurons. Neuron 20: 763772. | |
| Hedgecock EM and Russell RL (1975) Normal and mutant thermotaxis in the nematode C. elegans. Proceedings of the National Academy of Sciences of the USA 72: 40614065. | |
| Kimura KD, Tissenbaum HA, Liu Y and Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942946. | |
| Raymond CS, Shamu CE, Shen MM et al. (1998) Evidence for evolutionary conservation of sex-determining genes. Nature 391: 691695. | |
| Sulston JE, Schierenberg E, White JG and Thomson JN (1983) The embryonic cell lineage of the nematode C. elegans. Developmental Biology 100: 64119. | |
| White JG, Southgate E, Thomson JN and Brenner S (1986) The structure of the nervous system of the nematode C. elegans. Philosophical Transactions of the Royal Society of London 314B: 1340. | |
| Further Reading | |
| Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 7194. | |
| ePath Caenorhabditis elegans WWW Server. [http://elegans.swmed.edu/] | |
| Cline TW and Meyer BJ (1996) Vive la diffèrence: males vs females in flies vs worms. Annual Review of Genetics 30: 637702. | |
| Hamill OP and McBride DW (1996) A supramolecular complex underlying touch sensitivity. Trends in Neurosciences 19: 258261. | |
| Priess JR and Hirsh DI (1986) C. elegans morphogenesis: The role of the cytoskeleton in elongation of the embryo. Developmental Biology 117: 156173. | |
| book Riddle D, Blumenthal T, Meyer BJ and Priess JR (1997) C. elegans II. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. | |
| Tessier-Lavigne M and Goodman CS (1996) The molecular biology of axon guidance. Science 274: 11231133. | |
| Sundaram M and Han M (1996) Control and integration of cell signaling pathways during C. elegans vulval development. BioEssays 18: 473480. | |
| book Wood WB et al. (ed.) (1988) The Nematode "Caenorhabditis elegans". Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. | |