Adenosine Triphosphate

Adenosine triphosphate consists of the purine adenine linked through its N9 to d-ribose via a -N-glycosidic C(1¢) linkage; the -phosphoryl group is linked via an ester linkage to the alcoholic O of ribose (C5¢), and the - and -phosphoryl groups form anhydride bonds. The chemical energy stored in the anhydride bonds is released upon hydrolysis at the - or -phosphorus.

Keywords: structure; catalysis; metabolism; energy transduction

Figure 1. Structure of ATP. The purine base, adenine, is linked to d-ribose by a N-glycosidic bond. The 5¢ position of ribose is linked by an ester bond to P, which in turn is linked by an anhydride bond to P and P of a pyrophosphate moiety.
Figure 2. The processes that synthesize and utilize ATP.
Figure 3. A schematic representation of ATP synthase. The F1 component (33) is arranged in a flattened sphere of alternating and subunits. Together with the subunit, which anchors the c subunits, the rotatory motor is formed with the subunit as the drive shaft. F1 is further connected to F0, which is responsible for proton translocation, by a stalk consisting of the subunits and b2.
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 References
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 Further Reading
    book Alberts B, Johnson A, Lewis J et al. (2002) Molecular Biology of the Cell, 4th edn, part IV, section 14, New York, Garland Science.
    Becker PB and Horz W (2002) ATP-dependent nucleosome remodeling. Annual Review of Biochemistry 71: 247–273.
    Block SM (1997) Real engines of creation. Nature 386: 217–219.
    Cohn M (1990) Structural and chemical properties of ATP and its metal complexes in solution. Annals of the New York Academy of Sciences 603: 151–164.
    book Ernster L (ed.) (1984) Bioenergetics. Amsterdam: Elsevier Science Publishers.
    book Frey PA (1992) "Nucleotidyltransferases and phosphotransferases: stereochemistry and covalent intermediates". In: Sigman DS and Boyer PD (eds.) The Enzymes, vol. XX. San Diego: Academic Press.
    Hibberd MG and Trentham DR (1986) Relationships between chemical and mechanical events during muscular contraction. Annual Review of Biophysics and Biophysical Chemistry 15: 119–161.
    book Papa S, Guerreri F and Trager JM (1999) Frontiers of Cellular Energetics. Molecular Biology, Biochemistry, Physiopathology. New York: Kluver Academic/Plenum Publishers.
    Pedersen PL (ed.) (2000) ATP synthases in the year 2000. Current views about structure, motor components, energy interconversions and catalytic mechanisms. Journal of Bioenergetics and Biomembranes 32, part I: 325–421, part II: 423–546.
    Walker JE, Saraste M, Runswick MJ and Gay NJ (1982) Distantly related sequences in the and subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO Journal 1: 945–951.
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Cohn, Mildred(Sep 2005) Adenosine Triphosphate. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003881]