Saccharomyces cerevisiae: Applications
Mark H Pausch, Wyeth‐Ayerst Research, Princeton, New Jersey, USA
Donald R Kirsch, Wyeth‐Ayerst Research, Princeton, New Jersey, USA
Sanford J Silverman, Wyeth‐Ayerst Research, Princeton, New Jersey, USA
Published online: May 2005
DOI: 10.1038/npg.els.0003885
Abstract
The yeast Saccharomyces cerevisiae has traditionally found useful applications in the production of food and alcoholic beverages. The completed sequence of
its genome has revolutionized the use of yeast as a model system for the investigation of eukaryotic cell processes at a whole‐genome
level. The production of enzymes and recombinant proteins and the development of drug screening assays are commercial applications
of yeast cells.
Keywords: genome; transcriptome; proteome; two‐hybrid screening
Further Reading
Bartel PL and
Fields S (eds)
(1997)
The Yeast Two‐Hybrid System.
New York: Oxford University Press.
Broach JR,
Jones EW and
Pringle JR (eds)
(1998)
The Molecular Biology of the Yeast Saccharomyces cerevisiae.
Cold Spring Harbor, NY: Cold Spring Harbor Press.
Campbell MA
(2003)
Isotope‐Coded Affinity Tags (ICAT) technology.
http://www.bio.davidson.edu/Courses/genomics/ICAT/ICAT.html
(An animation of ICAT proteomic analysis technology using yeast.).
Guthrie C and
Fink GR (eds)
(1991)
Guide to Yeast Genetics and Molecular Biology. Methods in Enzymology,
194.
San Diego, CA: Academic Press.
MacDonald PN (ed.)
(2001)
Two‐Hybrid Systems: Methods and Protocols.
Totowa, NJ: Humana Press Inc.
World Wide Web Virtual Library
(2003)
Yeast (Budding, Fission, and Candida)
http://genome‐www.stanford.edu/Saccharomyces/VL‐yeast.html
(Section of the Virtual Library describing the yeast model organisms).