ATPases: Ion‐motive

Florent Guillain, CNRS, Grenoble, France
Elisabeth Mintz, CEA, Grenoble, France

Published online: April 2001

DOI: 10.1038/npg.els.0000678

Ion motive ATPases allow ion(s) to accumulate on one side of a biological membrane at the expense of ATP hydrolysis. In this way active transport across biological membranes is mediated.

Keywords: active transport; ion; ATP hydrolysis; pump structure; mechanism

Figure 1.  Ca2+ ATPase tertiary structure prediction, redrawn from Green and Stokes (1992). Note the phosphorylation site (D, aspartate) and the nucleotide site (K, lysine)
Figure 2.  Ca2+ ATPase shape, redrawn from Toyoshima et al. (1993).
Figure 3. V-ATPase motor, redrawn from Boekema et al. (1997). ATP hydrolysis in V1 headpiece induces rotation of the V1 stalk which in turn induces rotation of the V0 rotor. This mechanical energy is used for  H+ translocation.
Scheme 1. E1/E2 model for ion transport.
Scheme 2. Function of  Na+/K+ ATPase.
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 References
    Boekema EJ, Ubbink-Kok T, Lolkema JS, Brisson A and Konings WN (1997) Visualisation of a peripheral stalk in V-type ATPase: evidence for the stator structure essential to rotational catalysis. Proceedings of the National Academy of Sciences of the USA 94: 14291–14293.
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    Nakamoto RK and Slayman CW (1989) Molecular properties of the fungal plasma-membrane [H+]-ATPase. Journal of Bioenergetics and Biomembranes 21: 621–632.
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 Further Reading
    book Bittar EE and Andersen JP (eds) (1998) "Ion pumps". A special volume of Advances in Molecular and Cell Biology, vols 23A and 23B. London: JAI Press.
    Skou JC and Esmann M (1992) The Na+, K+-ATPase. Journal of Bioenergetics and Biomembranes 24: 249–261.
    Solioz M and Vulpe C (1996) CPx-type ATPases: a class of P-type ATPases that pump heavy metals. Trends in Biochemical Sciences 21: 237–241.

Related Sub-Topics:

Cell Membranes | Cellular Transport | Cell Compartments and Cellular Organelles | Membrane Proteins | Enzymes: Structure and Action Mechanism | Molecular Transport
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Article Title: ATPases: Ion‐motive
 
How to Cite close
Guillain, Florent, and Mintz, Elisabeth(Apr 2001) ATPases: Ion‐motive. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000678]