Elongation Factor 3 in Fungal Translation


Elongation factor 3 (EF‐3) is uniquely required by the fungal translational apparatus. Understanding its function may provide new insights into the mechanistic aspect of translation for all systems. The information in turn may lead to the development of potential antifungal drugs.

Keywords: protein synthesis; fungal protein; ribosome; ATP‐binding protein; RNA‐binding protein

Figure 1.

Representation of the reactions of the elongation cycle. EF, elongation factors; A, P and E represent the binding sites for aminoacyl‐, peptidyl‐ and deacyl‐tRNA on the ribosome shown by the corresponding symbols in the diagram. PRE and POST represent the pre‐ and the posttranslocational states of the ribosome. The reactions of the elongation cycle require guanosine triphosphate (GTP) for EF‐1α and EF‐2 function, adenosine triphosphate (ATP) for EF‐3 function. GDP, guanosine diphosphate; Pi, inorganic phosphate.



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Further Reading

Bianchet MA, Ko YH, Amzel M and Pedersen PL (1997) Modeling of nucleotide binding domains of ABC transporter proteins based on a Fl‐ATPase/recA topology: Structural model of the nucleotide binding domains of cystic fibrosis transmembrane conductance regulator. Journal of Bioenergetics and Biomembranes 29: 503–524.

Chakraburtty K (1999) Functional interaction of elongation factor 3 with yeast ribosomes. International Journal of Biochemistry and Cell Biology 31: 163–173.

Hershey JWB, Mathews MB and Sonenberg N (eds) (1996) Translational Control. New York: Cold Spring Harbor Laboratory Press.

Matheson AT, Davies JE, Dennis PP and Hill WE (eds) (1995) Frontiers in Translation, vol. 73. Ottawa, Canada: NRC Research Press.

Nierhaus KH, Franceschi F, Subramanian AR, Erdmann VA and Wittman‐Liebold B (eds) (1993) The Translational Apparatus. New York: Plenum Press.

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Chakraburtty, Kalpana(Apr 2001) Elongation Factor 3 in Fungal Translation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000686]