Developmental Biology of Synapse Formation
Federica Montanaro, Harvard University, Boston, Massachusetts, USA
Salvatore Carbonetto, McGill University, Montreal, Quebec, Canada
Published online: May 2003
DOI: 10.1038/npg.els.0000801
Abstract
Synapses are specialized sites for communication between neurons and their targets involved in the processing of information
and the generation of behaviour and thought. The formation of synapses during development and their remodelling involves a
complex bidirectional signalling between the neuron and its target.
Keywords: neuromuscular junction; neuronal synapses; synaptic elimination; synaptic plasticity; neurotransmitter
Further Reading
Bennett MR
(1999)
Synapse formation molecules in muscle and autonomic ganglia: the dual constraint hypothesis.
Progress in Neurobiology
57: 225–287.
Burden SJ
(1998)
The formation of neuromuscular synapses.
Genes and Development
12: 133–148.
Keshishian H,
Chiba A and
Bate M
(1996)
The Drosophila neuromuscular junction: a model system for studying synaptic development.
Annual Review of Neuroscience
19: 545–575.
Kim JH and
Huganir RL
(1999)
Organization and regulation of proteins at synapses.
Current Opinion in Cell Biology
11: 248–254.
Klintsova AY and
Greenough WT
(1999)
Synaptic plasticity in cortical systems.
Current Opinion in Neurobiology
9: 203–208.
Lohof AM,
Delhaye‐Bouchaud N and
Mariani J
(1996)
Synapse elimination in the central nervous system: functional significance and cellular mechanisms.
Reviews in the Neurosciences
7: 85–101.
Sanes JR and
Lichtman JW
(1999)
Development of the vertebrate neuromuscular junction.
Annual Review of Neuroscience
22: 389–442.
Shatz CJ
(1990)
Impulse connectivity and patterning of connections during CNS development.
Neuron
5: 745–756.