Trophic Support


The survival of neurons in the developing vertebrate nervous system is dependent on the supply of one or more neurotrophic factors. There are several families of these proteins, which may act by a paracrine or autocrine route.

Keywords: neurotrophic factor; neuronal survival; neurotrophin; CNTF; GDNF; HGF

Further Reading

Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annual Review of Neuroscience 18: 223–253.

Davies AM (1994) Role of neurotrophins in the developing nervous system. Journal of Neurobiology 25: 1334–1348.

Davies AM (1997) Neurotrophin switching: where does it stand? Current Opinion in Neurobiology 7: 110–118.

Davies AM (1997) The yin and yang of nerve growth factor. Current Biology 7: 38–40.

Lewin GR and Barde Y‐A (1996) Physiology of the neurotrophins. Annual Review of Neuroscience 19: 289–317.

Sendtner M, Carroll P, Holtmann B, Hughes RA and Thoenen H (1994) Ciliary neurotrophic factor. Journal of Neurobiology 25: 1436–1453.

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How to Cite close
Davies, Alun M(Apr 2001) Trophic Support. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0000803]