Burke H Judd, Chapel Hill, North Carolina, USA
Published online: April 2001
DOI: 10.1038/npg.els.0000814
Most model genetic systems share important characteristics that make them amenable to growth and analysis in the laboratory. These include genetic mapping by recombination, tests for dominance and complementation. Development of a system for transformation and obtaining the complete nucleotide sequence of the genome are also very important.
Keywords: gene mapping; dominance; recombination; complementation; transformation; tetrad analysis; polytene chromosomes
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Figure 1. Diagram depicting alternative lytic and lysogenic paths for lambda virus following its infecting an E. coli host cell.
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Figure 2. Life cycle of Saccharomyces cerevisiae depicting diploid and haploid vegetative cycles. Meiosis results in a tetrad of haploid ascospores of two mating types, a and alpha.
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Figure 3. Diagram depicting one method for creating mosaic transgenic mice using transformed
embryonic stem cells (ES cells) injected into a host blastocyst, which is placed in a surrogate mother for development.
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| Further Reading | |
| book Ashburner M (1989) Drosophila: A Laboratory Handbook. Cold Spring Harbor, NY: Cold Spring Harbor Press. | |
| book Darnell J, Lodish H and Baltimore D (1990) Molecular Cell Biology, 2nd edn. New York: WH Freeman. | |
| book Guthrie C and Fink GR (eds) (1991) Methods in Enzymology: Guide to Yeast Genetics and Molecular Biology. San Diego, CA: Academic Press. | |
| Lambie E and Kimble J (1991) Genetic control of cell interactions in nematode development. Annual Review of Genetics 25: 411–436. | |
| book Meyerowitz EM and Somerville CR (1994) Arabidopsis. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. | |
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