Regulatory Cascade
Johan Van Lint, Katholieke Universiteit Leuven, Leuven, Belgium
Jackie R Vandenheede, Katholieke Universiteit Leuven, Leuven, Belgium
Published online: April 2001
DOI: 10.1038/npg.els.0000867
Abstract
An enzyme cascade is a regulatory system where one enzyme catalyses the covalent modification of another enzyme. Regulatory
cascades are either unidirectional or cyclic; both types are important biological switches for the regulation of physiological
processes.
Keywords: cascades; protein phosphorylation; proteolysis; glycogen metabolism; blood clotting
References
Bollen M,
Keppens S and
Stalmans W
(1998)
Specific features of glycogen metabolism in the liver.
Biochemical Journal
336: 19–31.
Chock PB and
Stadtman ER
(1996)
Cyclic cascade in cellular regulation.
In: Bittar EE and
Bittar N (eds)
Principles of Medical Biology,
vol. 4:
Cell Chemistry and Physiology,
part II,
pp. 201–220.
Greenwich, CT: Jai Press.
Davie EW and
Fujikawa K
(1975)
Basic mechanisms in blood coagulation.
Annual Review of Biochemistry
44: 799–829.
Goldbeter A and
Koshland DE Jr
(1987)
Energy expenditure in the control of biochemical systems by covalent modification.
Journal of Biological Chemistry
262: 4460–4471.
Neurath H and
Walsh KA
(1976)
In: Ribbons EW and
Brew K (eds)
Proteolysis and Physiological Regulation,
pp. 29–40.
New York: Academic Press.
Shacter E,
Stadtman ER,
Jurgensen SR and
Chock PB
(1988)
Role of cAMP in cyclic cascade regulation.
Methods in Enzymology
159: 3–19.
Stadtman ER and
Chock PB
(1978)
Interconvertible enzyme cascades in metabolic regulation.
Current Topics in Cellular Regulation
13: 53–95.
Further Reading
Bollen M,
Keppens S and
Stalmans W
(1998)
Specific features of glycogen metabolism in the liver.
Biochemical Journal
336: 19–31.
Davie EW,
Fujikawa K and
Kisiel W
(1991)
The coagulation cascade: initiation, maintenance and regulation.
Biochemistry
30: 10363–10370.
Goldbeter A and
Wolpert L
(1990)
Covalent modification of proteins as a threshold mechanism in development.
Journal of Theoretical Biology
142: 243–250.
Schulz AR
(1998)
Control analysis of muscle glycogen metabolism.
Archives of Biochemistry and Biophysics
353: 172–180.