Nicole Gjertsen, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Michelle Collazo, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
William G Kerr, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Published online: December 2008
DOI: 10.1002/9780470015902.a0000902.pub2
Lymphoid cells (B cells and T cells) express antigen receptors which mediate the specific immune response. The development of lymphoid cells is tightly controlled to avoid autoreactivity and promote a diverse and useful repertoire of specificities.
Keywords: thymus; bone marrow; ontogeny; fetus; selection; natural killer (NK) cells
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Figure 1. Schematic depiction of B-cell development. See text for details.
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Figure 2. Schematic depiction of T-cell development. See text for details.
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Figure 3. Schematic depiction of NK cell development. NK development occurs in the bone marrow and requires several transcription factors and soluble factors. mNK cells in the periphery are able to produce cytokines and chemokines and are cytolytic.
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| Further Reading | |
| Blom B and Spits H (2006) Development of human lymphoid cells. Annual Review of Immunology 24: 287–320 [Human Lymphoid Development]. | |
| Di Santo JP (2006) Natural killer cell developmental pathways: a question of balance. Annual Review of Immunology 24: 257–286 [NK Lymphoid Development]. | |
| Hardy RR, Kincade PW and Dorshkind K (2007) The protean nature of cells in the B lymphocyte lineage. Immunity 26: 703–714 [B Lymphoid Development]. | |
| Weiner RS, Pelayo R and Kincade PW (2008) Evolving views on the genealogy of B cells. Nature Reviews. Immunology 8: 95–106. | |
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