Antibody Function

Abstract

Antibodies are members of the immunoglobulin family, and they comprise a principal component of the adaptive humoral immune response to foreign antigenic stimuli. Antibodies protect against infectious diseases by specifically recognizing a large universe of antigens and by mediating biological effector mechanisms, in concert with cells and other molecules, to neutralize and eliminate infectious agents and their products.

Keywords: antibody; immunoglobulin; variable region; constant region; fab; Fc

Figure 1.

An IgG molecule.

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References

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Further Reading

Alzari PM, Lascombe M‐B and Poljak RJ (1988) Three‐dimensional structure of antibodies. Annual Review of Immunology 6: 555–580.

Frazer JK and Capra JD (1999) Structure and function of antibodies. In: Paul WE (ed.) Fundamental Immunology, 4th edn, pp 37–74. Philadelphia: Lippincott‐Raven.

Honjo T and Alt FW (eds) (1995) Immunoglobulin Genes, 2nd edn. San Diego: Academic Press.

Ochs HD, Smith CIE and Puck JM (eds) (1998) Primary Immunodeficiency Diseases, A Molecular and Genetic Approach. Oxford: Oxford University Press.

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How to Cite close
Lucas, Alexander H(Jul 2003) Antibody Function. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0000907]