Immunological Accessory Molecules


Immunological accessory molecules are proteins expressed on the surface of immune cells that can modulate in a positive or negative manner the ability of the cell to develop or to perform one or more of its functions. Thus, accessory molecules are critical to the success or failure of controlling the immune response to foreign antigens such as infectious agents or organ transplants, the aberrant response to self‐antigens as in the case of autoimmune disease or the response to tumours.

Keywords: adhesion molecules; Fc receptors; tetraspanins; cytokine; chemokine; pattern recognition

Further Reading

Akira S, Uematsu S and Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783–801.

Kabelitz D (2007) Expression and function of Toll‐like receptors in T lymphocytes. Current Opinion in Immunology 19: 1–7.

Kohlmeier J and Benedict S (2003) Alternate costimulatory molecules in T cell activation: Differential mechanisms for directing the immune response. Histology and Histopathology 18: 1195–1204.

Kuby J, Kindt T, Goldsby R and Osborne B (2006) (eds) Immunology, pp. 338–359. New York: W.H. Freeman and Company.

Daëron M and Lesourne R (2006) Negative signaling in Fc receptor complexes. Advances in Immunology 89: 39–86.

Hemler ME (2005) Tetraspanin functions and associated microdomains. National Review of Molecular Cell Biology 6: 801–811.

Levy S and Shoham T (2005) The tetraspanin web modulates immune‐signaling complexes. Nature Reviews Immunology 5: 136–148.

Leonard W (2003) Type I cytokines and interferons and their receptors. In: Paul WE (ed.) Fundamental Immunology, pp. 497–517. Philadelphia, PA: Lippincott Williams & Wilkins.

Le Y, Zhou Y, Iribarren P and Ming Wang J (2004) Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cellular and Molecular Immunology 1(2): 95–104.

Sharpe A, Latchman Y and Greenwald R (2003) Accessory molecules and costimulation. In: Paul WE (ed.) Fundamental Immunology, pp. 393–417. Philadelphia, PA: Lippincott Williams & Wilkins.

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Benedict, Stephen H, Cool, Kelli M, Dotson, Abby L, and Chan, Marcia A(Dec 2007) Immunological Accessory Molecules. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0000923.pub2]