Jennifer L Lamoureux, University of North Dakota School of Medicine and Health Sciences, North Dakota, USA
David S Bradley, University of North Dakota School of Medicine and Health Sciences, North Dakota, USA
Published online: April 2007
DOI: 10.1002/9780470015902.a0000945
Inflammation is the body's reaction to injury or pathogenic invasion. The four cardinal signs of inflammation, redness, swelling, heat and pain are the result of the innate immune response producing soluble inflammatory mediators that recruit cells to the sites of infection via chemokine gradients and regulation of receptors and adhesion molecules.
Keywords: inflammation; cytokine; chemokine; interleukin; macrophage activation; cellular infiltration
| Further Reading | |
| Ali H, Haribabu B, Richardson RM and Snyderman R (1997) Mechanisms of inflammation and leukocyte activation. The Medical Clinics of North America 81: 1. | |
| Benoist C and Mathis D (2002) Mast cells in autoimmune disease. Nature 420: 875. | |
| book Janeway CA, Travers P, Walport M and Shlomchik MJ (2005) Immunobiology, 6th edn. New York: Garland Publishing. | |
| Lowry SF (1993) Cytokine mediators of immunity and inflammation. Archives of Surgery 128: 1235. | |
| Ono SJ, Nakamura T and Miyazaki D (2003) Chemokines: roles in leukocyte development, trafficking, and effector function. The Journal of Allergy and Clinical Immunology 111: 1185. | |
| book Paul WE (ed.) (2003) Fundamental Immunology, 5th edn. Philadelphia: Lippincott Williams and Wilkins. | |
| book Stevens (1996) Clinical Immunology and Serology: A Laboratory Perspective. Philadelphia: FA Davis. | |
| Woolley DE (2003) The mast cell in inflammatory arthritis. The New England Journal of Medicine 348: 1709. | |
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