Immunological tolerance refers to a reduction or complete inhibition of the ability of an individual to mount a specific immune response upon immunization.
Keywords: transplantation; autoimmunity; immune privilege; deletion; anergy; receptor editing
Immunological Tolerance: Mechanisms
Moncef Zouali, Inserm & University Paris Diderot‐Paris 7, France
Published online: September 2007
DOI: 10.1002/9780470015902.a0000950.pub2
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Figure 1. High- and low-dose tolerance. When a given antigen is used over a wide range of concentrations, intermediate doses induce immunity, and low and high doses induce tolerance.
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| References | |
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| Further Reading | |
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| Schwartz RH (1989) Acquisition of immunologic self-tolerance. Cell 57: 1073–1081. | |
