Evolutionary Developmental Biology: Homologous Regulatory Genes and Processes

Abstract

Traits in two species are classed as homologous when they are derived from a similar trait in a shared ancestor. Homology can exist at the levels of both anatomical structure and regulatory gene sequence, but homology in one of these does not necessarily imply homology in the other.

Keywords: homology; Urbilateria; heart; eye; appendage

Figure 1.

Hox cluster evolution. The genes are classified into four groups: ‘anterior’ (green), ‘zen’ (yellow), ‘central’ (blue) and ‘posterior’ (red), based upon sequence comparisons within the conserved (homeobox) region. Many taxa have gained hox genes by duplication of either single genes or whole clusters; others have lost hox genes. The clusters shown include mouse (vertebrate), sea urchin (echinoderm), Drosophila melanogaster (arthropod), Caenorhabditis elegans (nematode), Helobdella triserialis (annelid), Eleutheria hydrozoa (cnidarian). The Urbilateria cluster is hypothetical, and is based upon the range of orthologues detected in descendants. Empty boxes indicate hox genes whose existence is expected but not proven. Modified from Finnerty and Martindale (1998) The evolution of the Hox cluster: insights from outgroups. Current Opinion in Genetics and Development8: 681–687.

Figure 2.

The conserved dorsal–ventral patterning system of arthropods and vertebrates. Idealized body plans of (a) an arthropod (protostome), (b) a vertebrate (deuterostome). In the deuterostome, axial inversion has been accompanied by the development of a new mouth (deutero, second; stomo, mouth). (c) Fate map of Drosophila cellular blastoderm, viewed in transverse section, and showing the location of dpp and sog expression. During subsequent gastrulation, the mesoderm invaginates, bringing the two lateral bands of neurogenic ectoderm into ventral apposition. (d) Fate map of Xenopus blastula seen in a lateral view of the surface. The distribution of Bmp‐4 and chd transcripts changes as gastrulation proceeds, and that shown here corresponds with an early stage. During gastrulation, the mesoderm and endoderm layers invaginate through the blastopore so that the whole surface becomes ectodermal. Modified from Wolpert L (1998) Principles of Development, Current Biology Ltd., Oxford University Press.

Figure 3.

Hypothetical scenarios showing possible evolutionary histories of developmentally regulated genes, their expression patterns, their developmental mechanisms, and the structures to which they give rise. These four traits are shown mapped on to phylogenetic trees. In most cases (b–e), the genes are more ancient than the anatomical structures that become dependent upon them. Modified from Abouheif .

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References

Abouheif E (1997) Developmental genetics and homology: a hierarchical approach. Trends in Ecology and Evolution 12: 405–408.

Bodmer R and Venkatesh TV (1998) Heart development in Drosophila and vertebrates: conservation of molecular mechanisms. Developmental Genetics 22: 181–186.

De Robertis EM and Sasai Y (1996) A common plan for dorsoventral patterning in Bilateria. Nature 380: 37–40.

Gehring WJ (1996) Eye evolution. Science 272: 468–469.

Holley SA, Jackson PD, Sasai Y et al. (1995) A conserved system for dorsoventral patterning in insects and vertebrates involving sog and chordin. Nature 376: 249–253.

Panganiban G, Irvine SM, Lowe C et al. (1997) The origin and evolution of animal appendages. Proceedings of the National Academy of Sciences of the USA 94: 5162–5166.

Sasai Y, Lu B, Steinbeisser H and De Robertis EM (1995) Regulation of neural induction by the Chd and Bmp‐4 antagonistic patterning signals in Xenopus. Nature 376: 333–336.

Valentine JW, Jablonski D and Erwin DH (1999) Fossils, molecules and embryos: new perspectives on the Cambrian explosion. Development 126: 851–859.

Further Reading

Abouheif E, Akam M, Dickinson WJ et al. (1997) Homology and developmental genes. Trends in Genetics 13: 432–433.

Adoutte A, Balavoine G, Lartillot N and de Rosa R (1999) Animal evolution. The end of the intermediate taxa? Trends in Genetics 15: 104–108.

Bolker JA and Raff RA (1996) Developmental genetics and traditional homology. BioEssays 18: 489–494.

De Robertis EM (1997) The ancestry of segmentation. Nature 387: 25–26.

Halder G, Callaerts P and Gehring WJ (1995) New perspectives on eye evolution. Current Opinion in Genetics and Development 5: 602–609.

Harris WA (1997) Pax‐6: Where to be conserved is not conservative. Proceedings of the National Academy of Sciences of the USA 94: 2098–2100.

Harvey RP (1996) NK‐2 homeobox genes and heart development. Developmental Biology 178: 203–216.

Hogan BLM (1995) Upside‐down ideas vindicated. Nature 376: 210–211.

Wray GA and Abouheif E (1998) When is homology not homology? Current Opinion in Genetics and Development 8: 675–680.

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How to Cite close
Gaunt, Stephen J(Apr 2001) Evolutionary Developmental Biology: Homologous Regulatory Genes and Processes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001064]