Francis J Novembre, Yerkes Regional Primate Research Center, Atlanta, Georgia, USA
Published online: April 2001
DOI: 10.1038/npg.els.0001088
Simian retroviruses are enveloped viruses that contain a duplex RNA core. In general, viruses found in nonhuman primates constitute the closest relatives to human viruses, therefore a knowledge of these viruses is important for an understanding of their human counterparts, which induce significant morbidity and mortality.
Keywords: RNA virus; nonhuman primate; simian immunodeficiency virus; simian retrovirus; simian T‐cell lymphotropic virus; foamy virus
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Figure 1.
Electron photomicrographs of replicating simian retroviruses in culture, showing the comparative structure of the following viruses; (a) simian immunodeficiency virus in CEMx174 cells; (b) simian T‐cell lymphotropic virus in a cell line established from a seropositive baboon; (c) simian retrovirus in Raji cells; and (4) simian foamy virus growing in a human peripheral blood mononuclear cell culture. Courtesy of Eileen Breeding of the Yerkes Regional Primate Research Center (a–c) and Tom Folks and Cynthia Goldsmith of the Centers for Disease Control and Prevention (d). |
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Figure 2.
Genomic structure of four simian retroviruses: simian retrovirus ( |
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Figure 3.
Replication strategy of simian immunodeficiency virus ( |
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Further Reading
Coffin JM (1991) Retroviridae and their replication. In: Fields BN, Knipe DM, Chanock RM et al. (eds) Fundamental Virology 2nd edn, pp. 645–708. New York: Raven Press.
Franchini G and Reitz MS Jr (1994) Phylogenesis and genetic complexity of the nonhuman primate retroviridae. AIDS Research and Human Retroviruses 10: 1047–1060.
Fultz PN (1994) Simian T‐lymphotropic virus type I. In: Levy J (ed.) The Retroviridae, vol. 3, pp. 111–131. New York: Plenum.
Gardner MB (1994) The simian retroviruses. In: Levy J (ed.) The Retroviridae, vol. 3, pp. 133–176. New York: Plenum.
Neumann‐Haefelin D, Fleps U, Renne R and Schweizer M (1993) Foamy viruses. Intervirology 35: 196–207.
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