Different tissues and growth factors permit and direct limb patterning at the cellular and molecular level during regeneration in amphibians.
Keywords: regeneration; growth factors; transferrin; Distal-less; fibroblast growth factor
Regeneration: Growth Factors in Limb Regeneration
Karen Crawford, St. Mary's College of Maryland, St Mary's City, Maryland, USA
Published online: April 2001
DOI: 10.1038/npg.els.0001104
| References | |
| book Armstrong JB and Malacinski GM (1989) Developmental Biology of the Axolotl. New York: Oxford University Press. | |
| Martin GR (1998) The roles of FGFs in the early development of vertebrate limbs. Genes and Development 12: 1571–1586. | |
| Mescher AL, Connell E, Hsu C, Patel C and Overton B (1997) Transferrin is necessary and sufficient for the neural effect on growth in amphibian limb regeneration blastemas. Development, Growth and Differentiation 39: 15–22. | |
| Mullen LM, Bryant SV, Torok MA, Blumberg B and Gardiner DM (1996) Nerve dependency of regeneration: the role of Distal-less and FGF signaling in amphibian limb regeneration. Development 122: 3487–3497. | |
| book Stocum DL (1995) Wound Repair, Regeneration, and Artificial Tissues. Austin, TX: R G Landes. | |
| book Wallace H (1981) Vertebrate Limb Regeneration. Chichester: John Wiley & Sons. | |
| Yokoyama H, Yonei-Tamura S, Endo T et al. (2000) Mesenchyme with fgf-10 expression is responsible for regenerative capacity in Xenopus limb buds. Developmental Biology 219: 18–29. | |
| Further Reading | |
| D'Jamoos CA, McMahon G and Tsonis PA (1998) Fibroblast growth factor receptors regulate the ability for hindlimb regeneration in Xenopus laevis. Wound Repair and Regeneration 6: 388–397. | |
| Géraudie J and Ferretti P (1998) Gene expression during amphibian limb regeneration. International Review of Cytology 180: 1–50. | |
| book Tsonis PA (1996) Amphibian Limb Regeneration. Cambridge: Cambridge University Press. | |
