Regeneration of Bone

Daniel A Neufeld, University of South Dakota, Vermillion, South Dakota, USA
Khalid Mohammad, University of South Dakota, Vermillion, South Dakota, USA

Published online: April 2001

DOI: 10.1038/npg.els.0001107

The term bone regeneration is used either to describe bone repair or, more accurately, to describe bone formation in sites at which bone would not normally be expected to reform such as avulsion or amputation. Induced regeneration of bone is becoming one of the major success stories of biomedical research.

Keywords: regeneration; bone replacement; growth factors; osteogenesis; bone remodelling; bone growth

Figure 1. Normal bone repair varies with location and type of injury.
Figure 2. Guided tissue regeneration.
Figure 3. Toetip regeneration. Illustration of a rodent toetip indicating appropriately regenerated bone distal to the amputation level.
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 References
    Aaron A and Eilert R (1996) Results of the Wagner and Ilizarov methods of limb-lengthening. Journal of Bone and Joint Surgery 78-A: 20–29.
    Douglas B (1972) Conservative management of guillotine amputation of the finger in children. Australian Paediatric Journal 8: 86–89.
    Elbeshir E (1990) Spontaneous regeneration of the mandibular bone following hemimandibulectomy. British Journal of Oral and Maxillofacial Surgery 28: 128–130.
    book Ericksen E and Langdahl B (1995) "Bone remodelling and its consequences for bone structure". In: Odgaard A and Weinans H (eds) Bone Structure and Remodelling, pp. 25–36. Singapore: World Scientific
    Glowacki J, Kaban L, Murray J, Folkman J and Mulliken J (1981) Application of the biological principle of induced osteogenesis for craniofacial defects. Lancet 8227: 959–963.
    book Hall B (1992) Bone. Boca Raton: CRC Press.
    Howell T, Fiorellini J, Paquette D, Offenbacher S and Giannobile W (1997) A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. Journal of Periodontology 68: 1186–1193.
    Pecora G, Baek S, Rethnam S and Kim S (1997) Barrier membrane techniques in endodontic microsurgery. Dental Clinics of North America 41(3): 585–602.
    book Sailer H and Kolb E (1996) "Purified bovine bone morphogenetic protein for clinical use in difficult conditions of cranio-maxillofacial surgery". In: Lindholm T (ed.) Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, pp. 207–230. Austin: Academic Press
    Sanan A and Haines S (1997) Repairing holes in the head: a history of cranioplasty. Neurosurgery 40(3): 588–603.
    Scott G and King J (1994) A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. Journal of Bone and Joint Surgery 76-A: 820–826.
    book Turner C and Forwood M (1995) "Bone adaption to mechanical forces in the rat tibia". In: Odgaard and Weinans (eds) Bone Structure and Remodelling, pp. 65–78. Singapore: World Scientific
    Urist M (1965) Bone: Formation by autoinduction. Science 150: 893–899.
    Urist M, Kovacs S and Yates K (1986) Regeneration of an enchondroma defect under the influence of an implant of human bone morphogenetic protein. Journal of Hand Surgery. 11-A: 417.
    Wozney J, Rosen V, Celeste A et al. (1998) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528–1534.
    Zhao W and Neufeld D (1995) Bone regrowth in young mice stimulated by nail organ. Journal of Experimental Zoology 271: 155–159.
 Further Reading
    book Bilezikian J, Raisz L and Gideon R (1995) Principles of Bone Biology. San Diego: Academic Press.
    book Lindholm T (1996) Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery. Austin: Academic Press.
    book Odgaard A and Weinans H (1994) Bone Structure and Remodelling. Singapore: World Scientific.
    book Rabie A and Urist M (1997) Bone Formation and Repair. Amsterdam: Elsevier.
    book Rosen V and Thies R (1995) The Cellular and Molecular Basis of Bone Formation and Repair. Austin: RG Landes.

Related Sub-Topics:

Genes, Molecules and Cellular Processes | Regeneration: Vertebrates
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Article Title: Regeneration of Bone
 
How to Cite close
Neufeld, Daniel A, and Mohammad, Khalid(Apr 2001) Regeneration of Bone. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001107]