Regeneration of Bone


The term bone regeneration is used either to describe bone repair or, more accurately, to describe bone formation in sites at which bone would not normally be expected to reform such as avulsion or amputation. Induced regeneration of bone is becoming one of the major success stories of biomedical research.

Keywords: regeneration; bone replacement; growth factors; osteogenesis; bone remodelling; bone growth

Figure 1.

Normal bone repair varies with location and type of injury.

Figure 2.

Guided tissue regeneration.

Figure 3.

Toetip regeneration. Illustration of a rodent toetip indicating appropriately regenerated bone distal to the amputation level.



Aaron A and Eilert R (1996) Results of the Wagner and Ilizarov methods of limb‐lengthening. Journal of Bone and Joint Surgery 78‐A: 20–29.

Douglas B (1972) Conservative management of guillotine amputation of the finger in children. Australian Paediatric Journal 8: 86–89.

Elbeshir E (1990) Spontaneous regeneration of the mandibular bone following hemimandibulectomy. British Journal of Oral and Maxillofacial Surgery 28: 128–130.

Ericksen E and Langdahl B (1995) Bone remodelling and its consequences for bone structure. In: Odgaard A and Weinans H (eds) Bone Structure and Remodelling, pp. 25–36. Singapore: World Scientific

Glowacki J, Kaban L, Murray J, Folkman J and Mulliken J (1981) Application of the biological principle of induced osteogenesis for craniofacial defects. Lancet 8227: 959–963.

Hall B (1992) Bone. Boca Raton: CRC Press.

Howell T, Fiorellini J, Paquette D, Offenbacher S and Giannobile W (1997) A phase I/II clinical trial to evaluate a combination of recombinant human platelet‐derived growth factor‐BB and recombinant human insulin‐like growth factor‐I in patients with periodontal disease. Journal of Periodontology 68: 1186–1193.

Pecora G, Baek S, Rethnam S and Kim S (1997) Barrier membrane techniques in endodontic microsurgery. Dental Clinics of North America 41(3): 585–602.

Sailer H and Kolb E (1996) Purified bovine bone morphogenetic protein for clinical use in difficult conditions of cranio‐maxillofacial surgery. In: Lindholm T (ed.) Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery, pp. 207–230. Austin: Academic Press

Sanan A and Haines S (1997) Repairing holes in the head: a history of cranioplasty. Neurosurgery 40(3): 588–603.

Scott G and King J (1994) A prospective, double‐blind trial of electrical capacitive coupling in the treatment of non‐union of long bones. Journal of Bone and Joint Surgery 76‐A: 820–826.

Turner C and Forwood M (1995) Bone adaption to mechanical forces in the rat tibia. In: Odgaard and Weinans (eds) Bone Structure and Remodelling, pp. 65–78. Singapore: World Scientific

Urist M (1965) Bone: Formation by autoinduction. Science 150: 893–899.

Urist M, Kovacs S and Yates K (1986) Regeneration of an enchondroma defect under the influence of an implant of human bone morphogenetic protein. Journal of Hand Surgery. 11‐A: 417.

Wozney J, Rosen V, Celeste A et al. (1998) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528–1534.

Zhao W and Neufeld D (1995) Bone regrowth in young mice stimulated by nail organ. Journal of Experimental Zoology 271: 155–159.

Further Reading

Bilezikian J, Raisz L and Gideon R (1995) Principles of Bone Biology. San Diego: Academic Press.

Lindholm T (1996) Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery. Austin: Academic Press.

Odgaard A and Weinans H (1994) Bone Structure and Remodelling. Singapore: World Scientific.

Rabie A and Urist M (1997) Bone Formation and Repair. Amsterdam: Elsevier.

Rosen V and Thies R (1995) The Cellular and Molecular Basis of Bone Formation and Repair. Austin: RG Landes.

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How to Cite close
Neufeld, Daniel A, and Mohammad, Khalid(Apr 2001) Regeneration of Bone. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0001107]