Regeneration: Principles
Charles E Dinsmore, Rush Medical College, Chicago, Illinois, USA
Published online: April 2001
DOI: 10.1038/npg.els.0001112
Abstract
Biological regeneration, a fundamental capacity of all living things, includes processes ranging from the constitutive turnover
of cellular components to the extraordinary ability of bisected hydra to become two structurally complete individuals or of
salamanders to replace amputated limbs and tails. While historical debate over the nature of regeneration relied largely on
its superficial similarity to embryonic development, advances in molecular biology and developmental genetics have now demonstrated
a striking concordance between development and regeneration that reaches across phyla.
Keywords: epimorphic regeneration; history; principles
Further Reading
Dinsmore CE (ed.)
(1991)
A History of Regeneration Research: Milestones in the Evolution of a Science.
New York: Cambridge University Press.
Ferretti P and
Géraudie J (eds.)
(1998)
Cellular and Molecular Basis of Regeneration: From Invertebrates to Humans.
Chichester: John Wiley & Sons.
Goss RJ
(1969)
Principles of Regeneration.
New York: Academic Press.
Lenhoff S and
Lenhoff H
(1986)
Hydra and the Birth of Experimental Biology – 1744: Abraham Trembley's Memoirs Concerning the Natural History of the Freshwater Polyp with Arms Shaped Like Horns.
Pacific Grove, CA: Boxwood Press.
Stocum DL
(1995)
Wound Repair, Regeneration and Artificial Tissues.
Molecular Biology Intelligence Unit Series, Austin, TX: RG Landes Co.
Trembley A
(1744)
Mémoires, pour servir à l′histoire d′un genre de polypes d′eau douce, à bras en forme de cornes.
Leide: Verbeek.
