Hypersensitivity: Antibody‐mediated Cytotoxic (Type II)

Abstract

Few disease states occur on the basis of a single hypersensitivity reaction. Type II hypersensitivity reactions cause tissue damage without the involvement of lymphocytes.

Keywords: hypotension; perforin; agglutination; goodpasture syndrome

Figure 1.

Antibody acts as an opsonin, leading to phagocytosis of the target cell.

Figure 2.

Antibody‐dependent cellular cytotoxicity (ADCC). Effector cell binding antibody on the target cell leads to lysis of target cell.

Figure 3.

C3b associated with antibody acts as an opsonin, leading to phagocytosis of the target cell.

Figure 4.

Bound antibody leads to activation of complement and lysis of the target cell by the membrane attack complex (MAC).

Figure 5.

Goodpasture syndrome. There is linear staining of immunoglobulin G along the glomerular basement membrane. Courtesy of Dr Robert Colvin, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Figure 6.

Right eye of a patient with chronic cicatrizing conjunctivitis, which proved on biopsy to be ocular cicatricial pemphigoid. Note the presence of a symblepharon inferotemporally.

Figure 7.

Ocular cicatricial pemphigoid. This immunofluorescent stain demonstrates linear deposition of immunoglobulin G along the basement membrane zone of the conjunctival epithelium.

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References

Berlot G, Tomasini A, Silvestri L and Gullo A (1998) Plasmapheresis in the critically ill patient. Kidney International 53(S63): S178–181.

Bolton WK (1996) Goodpasture's syndrome. Kidney International 50(5): 1753–1766.

Butterworth AE, Sturrock RF, Houba V and Rees PH (1974) Antibody‐dependent cell‐mediated damage to schistosumula in vitro. Nature 252: 503–505.

Carrol MC and Fischer MB (1997) Complement and the immune response. Current Opinion in Immunology 9: 64–69.

Daeron M (1997) Fc receptor biology. Annual Review of Immunology 15: 203–234.

Hartwell EA (1998) Use of Rh immune globulin: ASCP practice parameter. American Society of Clinical Pathologists. American Journal of Clinical Pathology 110(3): 281–292.

Jeter EK and Spivey MA (1995) Noninfectious complications of blood transfusion. Hematology/Oncology Clinics of North America 9(1): 187–204.

Kalluri R, Gunwar S, Reeders ST et al. (1991) Goodpasture syndrome: localization of the epitope for the autoantibodies to the carboxyl‐terminal region of the α3(IV) chain of basement membrane collagen. Journal of Biological Chemistry 266(35): 24018–24024.

Kalluri R, Gattone VH, Noelken ME and Hudson BG (1994) The alpha3 chain of type IV collagen induces autoimmune Goodpasture's syndrome. Proceedings of the National Academy of Sciences of the USA 91: 6201–6205.

Kelly PT and Haponik EF (1994) Goodpasture's syndrome: molecular and clinical advances. Medicine (Baltimore) 73(4): 171–185.

Nguyen QD and Foster CS (1996) Cicatricial Pemphigoid: Diagnosis and Treatment. IOC.

Quinones S, Bernal D, Garcia‐Sogo M, Elena SF and Saus J (1992) Exon/intron structure of the human α3(IV) gene encompassing the Goodpasture antigen (α3(IV)NC1). Journal of Biological Chemistry 267(28): 19780–19784.

Ravetch JV and Clines RA (1998) Divergent roles for Fc receptors and complement in vivo. Annual Review of Immunology 16: 421–432.

Roitt IM (1997) Essential Immunology, 9th edn. Oxford, UK: Blackwell Science.

Terada K, Tanaka H, Mori R, Katuoka N and Uchikawa M (1998) Hemolytic anemia associated with cold agglutinin during chickenpox and a review of the literature. Journal of Pediatric Hematology and Oncology 20(2): 149–151.

Tyagi S, Bohl K, Natarajan K et al. (1996) Ocular cicatricial pemphigoid antigen: partial sequence and biochemical characterization. Proceedings of the National Academy of Sciences of the USA 93: 14714–14719.

Wyngaarden JB, Smith LH and Bennet JC (1992) Cecil Textbook of Medicine, 19th edn. Saunders.

Yagita H, Nakata M, Kawasaki A, Shinkai Y and Okumura K (1992) Role of perforin in lymphocyte‐mediated cytolysis. Advances in Immunology 51: 215–235.

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How to Cite close
Samson, C Michael, and Foster, C Stephen(Apr 2001) Hypersensitivity: Antibody‐mediated Cytotoxic (Type II). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001137]