Hypersensitivity: Antibody‐mediated Cytotoxic (Type II)


Few disease states occur on the basis of a single hypersensitivity reaction. Type II hypersensitivity reactions cause tissue damage without the involvement of lymphocytes.

Keywords: hypotension; perforin; agglutination; goodpasture syndrome

Figure 1.

Antibody acts as an opsonin, leading to phagocytosis of the target cell.

Figure 2.

Antibody‐dependent cellular cytotoxicity (ADCC). Effector cell binding antibody on the target cell leads to lysis of target cell.

Figure 3.

C3b associated with antibody acts as an opsonin, leading to phagocytosis of the target cell.

Figure 4.

Bound antibody leads to activation of complement and lysis of the target cell by the membrane attack complex (MAC).

Figure 5.

Goodpasture syndrome. There is linear staining of immunoglobulin G along the glomerular basement membrane. Courtesy of Dr Robert Colvin, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Figure 6.

Right eye of a patient with chronic cicatrizing conjunctivitis, which proved on biopsy to be ocular cicatricial pemphigoid. Note the presence of a symblepharon inferotemporally.

Figure 7.

Ocular cicatricial pemphigoid. This immunofluorescent stain demonstrates linear deposition of immunoglobulin G along the basement membrane zone of the conjunctival epithelium.



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Samson, C Michael, and Foster, C Stephen(Apr 2001) Hypersensitivity: Antibody‐mediated Cytotoxic (Type II). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001137]