Gene Duplication and Redundancy

Abstract

Gene duplications create one or more copies of a gene in a genome. They are important forces of genome evolution which change genome size and lead to the evolution of new gene functions.

Keywords: genome evolution; natural selection; gene knockout

Figure 1.

Gene duplications can occur via (a) unequal crossing‐over or (b) retroposition (see text for details).

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Further Reading

Elder JF and Turner BJ (1995) Concerted evolution of repetitive DNA sequences in eukaryotes. Quarterly Review of Biology 70: 297–320.

Hillis DM and Dixon MT (1991) Ribosomal DNA: molecular evolution and phylogenetic inference. Quarterly Review of Biology 66: 410–453.

Li W‐H (1997) Molecular Evolution. Sunderland, MA: Sinauer.

Liao DQ (2000) Gene conversion drives within genic sequences: concerted evolution of ribosomal RNA genes in bacteria and archaea. Journal of Molecular Evolution 51: 305–317.

Lynch M and Conery JS (2000) The evolutionary fate and consequences of duplicate genes. Science 290: 1151–1155.

Ohno S (1970) Evolution by Gene Duplication. New York: Springer.

Romero D and Palacios R (1997) Gene amplification and genomic plasticity in prokaryotes. Annual Review of Genetics 31: 91–111.

Saks ME, Sampson JR and Abelson J (1998) Evolution of a transfer RNA gene through a point mutation in the anticodon. Science 279: 1665–1670.

Wagner A (1999) Redundant gene functions and natural selection. Journal of Evolutionary Biology 12: 1–16.

Wagner A (2000) Mutational robustness in genetic networks of yeast. Nature Genetics 24: 355–361.

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How to Cite close
Wagner, Andreas(Feb 2003) Gene Duplication and Redundancy. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001163]