Immunodeficient Animals


The creation of targeted mutations in the mouse and other animals has considerable utility in many areas of research in mammalian biology, and animals with well‐defined immune defects provide an excellent model for study of the immune system. Gene targeted knockout mice are widely used in exploring the mechanisms underlying the development and function of the immune system.

Keywords: mouse; immunodeficient; immune defect; gene knockout; gene targeting; immunological disorder


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Further Reading

Janeway CA and Travers P (1999) Immunobiology: The Immune System in Health and Disease. New York: Garland Publishing.

Ochs HD, Smith CIEand Puck JM (eds) (1999) Primary Immunodeficiency Diseases: A Molecular And Genetic Approach. New York: Oxford University Press.

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Berglöf, Anna, Sandstedt, Karin, and Smith, CI Edvard(Apr 2001) Immunodeficient Animals. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0001209]