Myeloid Cell Differentiation

Abstract

Myeloid cell differentiation is the process by which stem cells develop into various types of mature blood cell. This is achieved by the sequential activation of sets of genes, which produce the proteins that direct cell development and confer the specific properties of blood cells. Disruption of this process is believed to result in leukaemia.

Keywords: myeloid; differentiation; leukaemia; translocation

Figure 1.

The steps of myeloid cell differentiation, from pluripotent stem cell to differentiated cells. Transcription factors identified as necessary for a specific stage of differentiation are indicated.

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References

Daghman NA, McHale CM, Savage GM et al. (1999) Regulation of erythropoietin gene expression depends on two different oxygen‐sensing mechanisms. Molecular Genetics and Metabolism 67: 113–117.

Liu F, Poursine‐Laurent J, Wu HY and Link DC (1997) Interleukin‐6 and the granulocyte colony‐stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 90: 2583–2590.

McKercher S, Torbett BE, Anderson KL et al. (1996) Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO Journal 15: 5647–5658.

Neubauer H, Cumano A, Muller M et al. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93: 397–409.

Nishinakamura R, Miyajima A, Mee PJ, Tybulewicz VL and Murray R (1996) Hematopoiesis in mice lacking the entire granulocyte‐macrophage colony‐stimulating factor/interleukin‐3/interleukin‐5 functions. Blood 88: 2458–2464.

Palis J, Robertson S, Kennedy M, Wall C and Keller G (1999) Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126: 5073–5084.

Reissmann KR and Udupa KB (1978) Effect of inflammation on erythroid precursors (BFU‐E and CFU‐E) in bone marrow and spleen of mice. Journal of Laboratory and Clinical Medicine 92: 22–29.

Robb L, Lyons I, Li R et al. (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proceedings of the National Academy of Sciences of the USA 92: 7075–7079.

Socolovsky M, Fallon AEJ, Wang S, Brugnara C and Lodish HF (1999) Fetal anemia and apoptosis of red cell progenitors in Stata−/−5b−/− mice: a direct role for Stat5 in Bcl‐XL induction. Cell 98: 181–191.

Further Reading

Aringer M, Cheng A, Nelson JW et al. (1999) Janus kinases and their role in growth and disease. Life Science 64: 2173–2186.

Begley CG and Green AR (1999) The SCL gene: from case report to critical hematopoietic regulator. Blood 93: 2760–2770.

Greenberg PL (1998) Apoptosis and its role in the myelodysplastic syndromes: implications for disease natural history and treatment. Leukemia Research 22: 1123–1136.

Lawson ND and Berliner N (1999) Neutrophil maturation and the role of retinoic acid. Experimental Hematology 27: 1355–1367.

Lyman SD and Jacobsen SEW (1998) C‐kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 91: 1101–1134.

Rowley JD (1999) The role of chromosome translocations in leukemogenesis. Seminars in Hematology 36 (supplement 7): 52–72.

Shivdasani RA and Orkin SH (1996) The transcriptional control of hematopoiesis. Blood 87: 4025–4039.

Takahashi K, Naito M and Takeya M (1996) Development and heterogeneity of macrophages and their related cells through their differentiation pathways. Pathology International 46: 473–485.

Van Oostveen JW, Bijl JJ, Raaphorst FM, Walboomers JJM and Meijer CJLM (1999) The role of homeobox genes in normal hematopoiesis and hematological malignancies. Leukemia 13: 1675–1690.

Whetton AD and Spooncer E (1998) Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells. Current Opinion in Cell Biology 10: 721–726.

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How to Cite close
Biggs, Joseph R, and Kraft, Andrew S(Apr 2001) Myeloid Cell Differentiation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001218]