Myeloid Cell Differentiation

Joseph R Biggs, University of Colorado, Denver, Colorado, USA
Andrew S Kraft, University of Colorado, Denver, Colorado, USA

Published online: April 2001

DOI: 10.1038/npg.els.0001218

Myeloid cell differentiation is the process by which stem cells develop into various types of mature blood cell. This is achieved by the sequential activation of sets of genes, which produce the proteins that direct cell development and confer the specific properties of blood cells. Disruption of this process is believed to result in leukaemia.

Keywords: myeloid; differentiation; leukaemia; translocation

Figure 1. The steps of myeloid cell differentiation, from pluripotent stem cell to differentiated cells. Transcription factors identified as necessary for a specific stage of differentiation are indicated.
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Related Sub-Topics:

Cells of the Immune System | Cell Differentiation and Stem Cells
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Article Title: Myeloid Cell Differentiation
 
How to Cite close
Biggs, Joseph R, and Kraft, Andrew S(Apr 2001) Myeloid Cell Differentiation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001218]