Transplantation

Abstract

Transplantation is the transfer of cells, tissues or organs from one individual to another for a variety of purposes. It is important because it involves the replacement of missing, defective or damaged organs.

Keywords: transplantation; histocompatibility; grafts

Figure 1.

The histocompatibility antigens encoded by the class‐I and class‐II loci of the HLA complex. The class‐I molecules are expressed on the surface of all nucleated cells in the body; class‐II molecules are expressed on a subset of cells, primarily those, such as dendritic cells, macrophages and B lymphocytes that are engaged in antigen processing and presentation. The class‐I and class‐II loci are highly polymorphic.

Figure 2.

Segregation of HLA genes within a family. Because the HLA genes are so closely linked, those present on a given member of a chromosome pair are usually transmitted to the next generation as a unit (called a haplotype). The genes are inherited in a Mendelian fashion so that a given offspring has approximately a one‐fourth chance of having a full sibling inheriting the same combination.

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Further Reading

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How to Cite close
Melvold, Roger W(Sep 2005) Transplantation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003997]