Vikas Gupta, Princess Margaret Hospital, Toronto, Ontario, Canada
Christine Chen, Princess Margaret Hospital, Toronto, Ontario, Canada
Armand Keating, Princess Margaret Hospital, Toronto, Ontario, Canada
Published online: July 2007
DOI: 10.1002/9780470015902.a0001247.pub2
Haematopoietic stem cell transplantation involves the infusion of blood progenitor cells (stem cells) into patients with damaged bone marrow in order to restore normal marrow function. Stem cells may be obtained from a healthy donor (allogeneic) or from the patients themselves (autologous).
Keywords: stem cells; transplantation; haematopoietic; malignancy; graft
|
Figure 1. Indications for haematopoietic stem cell transplantation in North America in 2003. (Reproduced by permission of Dr. Mary Horowitz, Centre for International Blood and Marrow Transplant Research (CIBMTR).)
|
|
Figure 2. Causes of death after autologous and allogeneic transplants using matched sibling or unrelated donors. (Reproduced by permission of Dr. Mary Horowitz, CIBMTR.)
|
| References | |
| Attal M, Harousseau JL, Stoppa AM et al. (1996) A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. New England Journal of Medicine 335: 91–97. | |
| Bader P, Beck J, Frey A et al. (1998) Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT. Bone Marrow Transplant 21: 487–495. | |
| Barker JN, Weisdorf DJ, DeFor TE et al. (2005) Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 105: 1343–1347. | |
| Baron F, Maris MB, Sandmaier BM et al. (2005) Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. Journal of Clinical Oncology 23: 1993–2003. | |
| Burnett AK, Goldstone AH, Stevens RM et al. (1998) Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. UK Medical Research Council Adult and Children's Leukaemia Working Parties. Lancet 351: 700–708. | |
| Cassileth PA, Harrington DP, Appelbaum FR et al. (1998) Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. New England Journal of Medicine 339: 1649–1656. | |
| Flomenberg N, Devine SM, Dipersio JF et al. (2005) The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. Blood 106: 1867–1874. | |
| Gluckman E, Rocha V and Chastang C (1999) Cord blood stem cell transplantation. Bailliere's Best Practice & Research Clinical Haematology 12: 279–292. | |
| Huss R, Deeg HJ, Gooley T et al. (1996) Effect of mixed chimerism on graft-versus-host disease, disease recurrence and survival after HLA-identical marrow transplantation for aplastic anemia or chronic myelogenous leukemia. Bone Marrow Transplant 18: 767–776. | |
| Linch DC, Winfield D, Goldstone AH et al. (1993) Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. Lancet 341: 1051–1054. | |
| McCann SR, Bacigalupo A, Gluckman E et al. (1994) Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplant 13: 233–237. | |
| Philip T, Guglielmi C, Hagenbeek A et al. (1995) Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. New England Journal of Medicine 333: 1540–1545. | |
| Rocha V, Labopin M, Sanz G et al. (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New England Journal of Medicine 351: 2276–2285. | |
| Storb R, Blume KG, O’Donnell MR et al. (2001) Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers. Biology Blood and Marrow Transplantion 7: 39–44. | |
| Sung L, Buckstein R, Doyle JJ, Crump M and Detsky AS (2003) Treatment options for patients with acute myeloid leukemia with a matched sibling donor: a decision analysis. Cancer 97: 592–600. | |
Copyright © 2000-2013 by John Wiley & Sons, Inc., or related companies. All rights reserved.
