Autoimmune Disease: Genetics

Abstract

Autoimmune diseases result from an attack of the body's own tissues by the immune system. Genetic susceptibility and resistance to autoimmunity are primarily associated with highly polymorphic genes of the major histocompatibility complex and, to a lesser extent, with polygenic modifiers elsewhere in the genome.

Keywords: autoimmunity; polygenic; major histocompatibility complex‐linked genes; nonmajor histocompatibility complex‐linked genes; chromosomal mapping

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How to Cite close
Santamaria, Pere, and Yang, Yang(Sep 2005) Autoimmune Disease: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0004006]