Pere Santamaria, University of Calgary, Calgary, Alberta, Canada
Yang Yang, University of Calgary, Calgary, Alberta, Canada
Published online: September 2005
DOI: 10.1038/npg.els.0004006
Autoimmune diseases result from an attack of the body's own tissues by the immune system. Genetic susceptibility and resistance to autoimmunity are primarily associated with highly polymorphic genes of the major histocompatibility complex and, to a lesser extent, with polygenic modifiers elsewhere in the genome.
Keywords: autoimmunity; polygenic; major histocompatibility complex-linked genes; nonmajor histocompatibility complex-linked genes; chromosomal mapping
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