Protein–Protein Interactions

Jeremy H Lakey, University of Newcastle‐upon‐Tyne, UK
Isa Gokce, Gaziomanpasa University, Tokat, Turkey

Published online: April 2001

DOI: 10.1038/npg.els.0001346

Highly specific protein–protein interactions feature in all areas of biochemistry. The genome sequences now available are increasing both our knowledge of the protein composition of cells and the need to understand how they interact.

Keywords: binding; affinity; coiled-coils; antibody; quaternary structure

Figure 1. A section through a space-filling model of the complex between the viral protein GIII and its bacterial receptor protein TolA (dark). Note the close fit and deeply intermeshed surface of interaction.
Figure 2. The GCN4 leucine zipper peptide, showing one helix from each monomer. Leucines at the d position of the heptad repeats are shown in blue and the specificity-determining asparagine residues are shown in space-filling red.
Figure 3. Top view of the GCN4 leucine zipper with just the d leucines showing.
Figure 4. The arrangement of polypeptides in the membrane oligomer of the photosynthetic reaction centre. The extent of the membrane is shown by the box. Note how both helix–helix and extramembranous contacts stabilize the complex.
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 Further Reading
    book Branden C and Tooze J (1998) Introduction to Protein Structure, 2nd edn. London: Garland Publishing.
    book Cantor CR and Schimmel PR (1980) Biophysical Chemistry. New York: WH Freeman.
    book Creighton TE (1993) Proteins: Structures and Molecular Properties, 2nd edn. New York: WH Freeman.
    Deisenhofer J, Michel H and Huber R (1985) The structural basis of photosynthetic light reactions in bacteria. Trends in Biochemical Sciences 10: 243–248.
    Kuriyan J and Cowburn D (1997) Modular peptide recognition domains in eukaryotic signalling. Annual Review of Biophysics and Biomolecular Structure 26: 259–288.
    Lakey JH and Raggett EM (1998) Measuring protein–protein interactions. Current Opinion in Structural Biology 8(1): 119–123.
    Lubkowski J, Hennecke F, Pluckthun A and Wlodawer A (1999) Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA. Structure with Folding and Design 7(6): 711–722.
    O'Shea EK, Klemm JD, Kim PS and Alber T (1991) X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science 254: 539–544.
    Stites WE (1997) Protein–protein interactions: interface structure, binding thermodynamics and mutational analysis. Chemical Reviews 97(5): 1233–1250.
    book Stryer L (1995) Biochemistry, 4th edn. New York: WH Freeman.
    book Voet D and Voet JG (1995) Biochemistry, 2nd edn. New York: Wiley.

Related Sub-Topics:

Protein Structure | Biomolecular Interactions | Proteins: Structure, Function, Metabolism
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Article Title: Protein–Protein Interactions
 
How to Cite close
Lakey, Jeremy H, and Gokce, Isa(Apr 2001) Protein–Protein Interactions. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001346]