Protein–DNA Interactions: Polyelectrolyte Effects


The stability of noncovalent protein–DNA complexes is typically sensitive to the ionic composition of the solution, in a manner that is dependent on the specific ion concentrations and is not a simple ionic strength effect. One important origin of this sensitivity to solution conditions is the polyelectrolyte effect.

Keywords: Protein–nucleic acid interactions; thermodynamics; polyelectrolytes; binding


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Further Reading

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Lohman TM and Mascotti DP (1992) Thermodynamics of ligand–nucleic acid interactions. Methods in Enzymology 212: 400–424.

von Hippel P (2007) From “simple” DNA‐protein interactions to the macromolecular machines of gene expression. Annual Review of Biophysics and Biomolecular Structure 36: 79–105.

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How to Cite close
Saecker, Ruth M(Sep 2007) Protein–DNA Interactions: Polyelectrolyte Effects. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0001350.pub2]