James S Felton, Lawrence Livermore National Laboratory, Livermore, California, USA
Rebekah W Wu, Lawrence Livermore National Laboratory, Livermore, California, USA
Published online: July 2003
DOI: 10.1038/npg.els.0001413
The Ames/Salmonella mutation assay is the most widely used test to determine whether chemicals can cause genetic changes (mutations) potentially leading to cancer. Chemicals related to industry, farming, foods, drugs and the environment have been discovered to be mutagens with this simple assay.
Keywords: mutagen; carcinogen; ames/salmonella; metabolism; environmental chemical
| References | |
| Hagiwara Y, Watanabe M, Oda Y, Sofuni T and Nohmi T (1993) Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity. Mutation Research 291: 171–180. | |
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| Further Reading | |
| Tokiwa H and Ohnishi Y (1986) Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment. Critical Reviews in Toxicology 17: 23–60. | |
| Wakabayashi K, Nagao M, Esumi H and Sugimura T (1992) Food-derived mutagens and carcinogens. Cancer Research 52 (supplement): 2092s–2098s. | |
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