Ames/Salmonella Assay: A Bacterial Test for Mutagens

Abstract

The Ames/Salmonella mutation assay is the most widely used test to determine whether chemicals can cause genetic changes (mutations) potentially leading to cancer. Chemicals related to industry, farming, foods, drugs and the environment have been discovered to be mutagens with this simple assay.

Keywords: mutagen; carcinogen; ames/salmonella; metabolism; environmental chemical

References

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Further Reading

Tokiwa H and Ohnishi Y (1986) Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment. Critical Reviews in Toxicology 17: 23–60.

Wakabayashi K, Nagao M, Esumi H and Sugimura T (1992) Food‐derived mutagens and carcinogens. Cancer Research 52 (supplement): 2092s–2098s.

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How to Cite close
Felton, James S, and Wu, Rebekah W(Jul 2003) Ames/Salmonella Assay: A Bacterial Test for Mutagens. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001413]