Tumour Antigens Recognized by Antibodies

Andrew M Scott, Ludwig Institute for Cancer Research, Melbourne, Australia
Christoph Renner, Saarland University, Homberg/Saar, Germany

Published online: April 2001

DOI: 10.1038/npg.els.0001433

Antigens are frequently overexpressed on tumours, and the recognition of these antigens by antibodies can be used for tumour characterization, and for potential diagnostic and therapeutic purposes.

Keywords: tumour; antigens; antibodies; serology; immunohistochemistry

Figure 1. Immunohistochemical detection of tumour cell surface and stromal antigens in breast cancer. The red staining corresponds to human fibroblast activation protein (FAP) expression on fibroblasts in the stroma of the tumour. The brown staining corresponds to Ley antigen expression on the cell surface of the breast cancer cells.
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 Further Reading
    Heath JK, White JJ, Johnstone CN et al. (1997) The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. Proceedings of the National Academy of Sciences of the USA 94: 469–474.
    Oettgen HF, Rettig WJ, Lloyd KO and Old LJ (1990) Serological analysis of human cancer. Immunology and Allergy Clinics of North America 10(4): 607–637.
    Old LJ (1996) Immunotherapy for Cancer. Scientific American September: 136–143.
    Old LJ and Chen YT (1998) New paths in human cancer serology. Journal of Experimental Medicine 187: 1163–1167.
    book Rettig WF (1998) "Antigens, cell surface". In: Delves PJ and Roitt IM (eds) Encyclopedia of Immunology, vol. 1, pp. 207–214. San Diego: Academic Press.
    Ritter G and Livingston PO (1991) Ganglioside antigens expressed by human cancer cells. Seminars in Cancer Biology 2: 401–409.
    Sahin U, Tureci D, Schmitt H et al. (1995) Human neoplasms elicit multiple specific immune responses in the autologous host. Proceedings of the National Academy of Sciences of the USA 92: 11810–11813.
    Scott AM and Welt S (1997) Antibody-based immunological therapies. Current Opinion in Immunology 9: 717–722.

Related Sub-Topics:

Diagnostics, Therapeutics and Methods | Antibodies | Antigens | Tumour Immunology | Cell Biology of Cancer
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Article Title: Tumour Antigens Recognized by Antibodies
 
How to Cite close
Scott, Andrew M, and Renner, Christoph(Apr 2001) Tumour Antigens Recognized by Antibodies. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001433]