Placental Immune Defences – Protection Against Rejection and Infection

Abstract

The placenta must not only provide nutrients and take care of fetal waste products, it also needs to protect the fetus from maternal immunological attacks while at the same time transmitting maternal immunoglobulins to ensure protection against infectious agents.

Keywords: placenta; trophoblast; pregnancy; fetal rejection; immunoglobulin

Figure 1.

Schematic picture of the attachment and implantation of the blastocyst. (a) The human blastocyst attaches to the uterine epithelium at day 6–7 and some cells start to form the syncytiotrophoblast. In mice, attachment of the blastocyst takes place around day 4. (b) During the process of implantation in humans (day 8), the invasive syncytiotrophoblast proliferates and actively pulls the blastocyst into the uterine wall.

Figure 2.

Schematic drawing of the human placenta and organization of the fetal membranes. The tree‐like structure of the chorionic villi constitutes the part of the human placenta where maternofetal exchange of nutrients and waste occurs. The yolk sac can be observed between the amnion and the chorion in early pregnancy. By the end of the third month, the amnion and chorion have fused.

Figure 3.

Schematic drawing of the mouse placenta and organization of the fetal membranes. The chorioallantoic placenta consists of the labyrinthine trophoblast (the area of maternofetal interdigitation) and the spongiotrophoblast. Giant trophoblast cells constitute the border to the maternal decidua basalis. In contrast to the human fetus, the mouse fetus is enclosed by the yolk sac.

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References

Arvola M, Gustafsson E, Svensson L et al. (2000) Immunoglobulin‐secreting cells of maternal origin can be detected in B cell‐deficient mice. Biology of Reproduction 63: 1817–1824.

Baban B, Chandler P, McCool D et al. (2004) Indoleamine 2,3‐dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. Journal of Reproductive Immunology 61: 63–65.

Bennett WA, Lagoo‐Deenadayalan S, Whitworth NS et al. (1999) First‐trimester human chorionic villi express both immunoregulatory and inflammatory cytokines: a role for interleukin‐10 in regulating the cytokine network of pregnancy. American Journal of Reproductive Immunology 41: 70–78.

Catlin EA, Roberts JD, Erana R et al. (1999) Transplacental transmission of natural‐killer‐cell lymphoma. New England Journal of Medicine 341: 85–91.

Jauniaux E, Poston L and Burton GJ (2006) Placental‐related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Human Reproduction Update 12(6): 747–755.

Lapaire O, Holzgreve W, Oosterwijk JC, Brinkhouse R and Bianchi DW (2006) Georg Schmorl on trophoblasts in the maternal circulation. Placenta In press.

Liljander M, Sällström M‐A, Andersson S et al. (2006) Identification of genetic regions of importance for reproductive performance in female mice. Genetics 173: 901–909.

Medawar PB (1953) Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Society of Experimental Biology Symposia VII 11: 320–338.

Molina H (2005) Complement regulation during pregnancy. Immunologic Research 32: 187–192.

Sharma JB, Sharma A, Bahadur A et al. (2006) Oxidative stress markers and antioxidant levels in normal pregnancy and pre‐eclampsia. International Journal of Gynecology and Obstetrics 94: 23–27.

Simister NE (2003) Placental transport of immunoglobulin G. Vaccine 21: 3365–3369.

Svensson L, Arvola M, Sällström M‐A, Holmdahl R and Mattsson R (2001) The Th2 cytokines IL‐4 and IL‐10 are not crucial for the completion of allogeneic pregnancy in mice. Journal of Reproductive Immunology 51: 3–7.

Trowsdale J and Betz AG (2006) Mother's little helpers: mechanisms of maternal‐fetal tolerance. Nature Immunology 7: 241–246.

Weetman AP (1999) The immunology of pregnancy. Thyroid 9: 643–646.

Wegmann TG, Lin H, Guilbert L and Mosmann TR (1993) Bidirectional cytokine interactions in the maternal–fetal relationship; is successful pregnancy a TH2 phenomenon? Immunology Today 14: 353–356.

Further Reading

Cross JC (2005) Placental function in development and disease. Reproduction, Fertility and Development 18: 71–76.

Mellor AL and Munn DH (1999) Tryptophan catabolism and T‐cell tolerance: immunosuppression by starvation? Immunology Today 20: 469–473.

Mincheva‐Nilsson L, Nagaeva O, Chen T et al. (2006) Placenta‐driven soluble MHC class I chain‐related molecules down‐regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel escape mechanism for fetal survival. Journal of Immunology 176: 3585–3592.

Petroff MG (2005) Immune interactions at the maternal‐fetal interface. Journal of Reproductive Immunology 68: 1–13.

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How to Cite close
Liljander, Maria, Arvola, Marie, and Mattsson, Ragnar(Jan 2007) Placental Immune Defences – Protection Against Rejection and Infection. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0001438.pub2]