Immunity: Experimental Transfer

Mogens H Claësson, The Panum Institute, The University of Copenhagen, Denmark
Jesper Hald, The University Hospital, Righospitalet, Denmark

Published online: April 2001

DOI: 10.1038/npg.els.0001440

Transfers of biological reagents, cellular or humoral, have been a central theme in experimental immunology, including many areas of tumour immunology. Such transfers include lymphokine-activated killer (LAK) cells, tumour-infiltrating lymphocytes (TILs) and antigen-specific cytotoxic T-cell (CTL) lines and clones, monoclonal antibodies (mAbs) and cytokines.

Keywords: T lymphocytes; cytokines; tumour immunology; allotolerance; chronic inflammation

 References
    Bregenholt S, Delbro D and Claësson MH (1997) T cell transfer and TCR/cytokine gene deletion models in the study of inflammatory bowel disease. APMIS 105: 655–662.
    Cheever MA, Thompson DB, Klarnet JP and Greenberg PD (1986) Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells. Journal of Experimental Medicine 163: 1100–1112.
    Embleton MJ, Charleston A, Robins RA, Pimm MV and Baldwin RW (1991) Recombinant ricin toxin A chain cytotoxicity against carcinoembryonic antigen expressing tumour cells mediated by a bispecific monoclonal antibody and its potentiation by ricin toxin B chain. British Journal of Cancer 63: 670–674.
    Finkelman FD and Maliszewski C (1997) Enhancing cytokine effects in vivo. Immunologist 5: 10–14.
    Gajewski TF, Fallarino F, Uyttenhove C and Boon T (1996) Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization. Journal of Immunology 156: 2909–2917.
    Henderson RA and Finn OJ (1996) Human tumor antigens are ready to fly. Advances in Immunology 62: 217–256.
    Jacobsen IM and Claësson MH (1998) Veto cell suppression mechanisms in prevention of allograft rejection. APMIS 106: 345–353.
    Jicha DL, Mule JJ and Rosenberg SA (1991) Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy. Journal of Experimental Medicine 174: 1511–1515.
    Kast WM, Offringa R, Peters PJ et al. (1989) Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes. Cell 59: 603–614.
    Kwon ED, Hurwitz AA, Foster BA et al. (1997) Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proceedings of the National Academy of Sciences of the USA 94: 8099–8103.
    Lanzavecchia A (1998) Licence to kill. Nature 393: 413–414.
    Nagy Z (1998) Immunological right of veto. Nature Biotechnology 16: 237–238.
    Nielsen OH, Vainer B, Bregenholt S, Claësson MH, Bishop PD and Kirman I (1997) Inflammatory bowel disease: Potential and therapeutic strategies. Cytokines, Cellular and Molecular Therapy 3: 267–281.
    Paleolog E (1997) Target effector role of vascular endothelium in the inflammatory response: insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis. Molecular Pathology 50: 225–233.
    Pardoll D (1992) Immunotherapy with cytokine gene-transduced tumor cells: the next wave in gene therapy for cancer. Current Opinion in Oncology 4: 1124–1129.
    Pardoll DM (1998) Cancer vaccines. Nature Medicine 4: 525–531.
    Reimann J, Rudolphi A and Claësson MH (1995) Novel experimental approaches in the study of the immunopathology in inflammatory bowel disease. Journal of Molecular Medicine 73: 133–140.
    Rosenberg SA and Lotze MT (1986) Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes. Annual Review of Immunology 4: 681–709.
    Stenholm ACO, Kirkin A and Zeuthen J (1998) In vivo eradication of an established human melanoma by an in vitro generated autologous cytotoxic T cell clone: a scid mouse model. International Journal of Cancer 77: 476–480.
    van de Winkel JGJ, Bast B and de Gast GC (1997) Immunotherapeutica potential of bispecific antibodies. Immunology Today 18: 562–564.
    Waldmann H and Cobbold S (1998) How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annual Review of Immunology 16: 619–644.
    Yee C, Riddell SR and Greenberg PD (1997) Prospects of adoptive T cell therapy. Current Opinion in Immunology 9: 702–708.
 Further Reading
    book Culver WK (1994) Gene Therapy – A Handbook for Physicians. New York: Mary Ann Liebert.
    book Janeway CA and Travers P (1997) Immunobiology. Edinburgh: Current Biology, Churchill Livingstone 1997.
    book Roitt I, Brostoff J and Male D (1996) Immunology, 4th edn. London: Times Mirror International.

Related Sub-Topics:

Cells of the Immune System | Vaccines | Diagnostics, Therapeutics and Methods
Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

Article Title: Immunity: Experimental Transfer
 
How to Cite close
Claësson, Mogens H, and Hald, Jesper(Apr 2001) Immunity: Experimental Transfer. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001440]