Gene Mapping: Comparative

Abstract

The construction of gene maps of vertebrate species allows for the comparison, between species, of gene arrangement and chromosome homology. This comparative approach is useful for predicting gene position and function, and for tracing the course of genome evolution.

Keywords: vertebrates; gene arrangement; chromosomes; chromosome painting; genome evolution

Figure 1.

The relationship of the major mammal groups. The divergence times, in millions of years before present, appear at each node.

Figure 2.

Comparative mapping of human chromosome 6. The genes on human chromosome 6 that have been mapped in other species (excluding just mouse) are represented at their location, and a symbol appears beside this gene in every other species in which it has been mapped. Symbols are joined in a vertical line where these genes lie on the same chromosome, and the number of this chromosome appears beside the line.

Figure 3.

Chromosomes of the swamp wallaby (a species with only five enormous chromosomes) are ‘painted’ with flourescence‐tagged DNA from individual chromosomes from the related tammar wallaby (a species with seven chromosomes). Tammar chromosome 2 (green); tammar chromosome 7 (pink); X chromosome (white). The same blocks of genome are present, but have been stuck together in the swamp wallaby.

close

References

Lichter P, Cremer T, Bordern J, Manuelidis L and Ward DC (1988) Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries. Human Genetics 80: 224–234.

O'Brien SJ, Seuanez HN and Womack JE (1988) Mammalian genome organization: an evolutionary view. Annual Review of Genetics 22: 323–351.

O'Brien SJ, Menotti‐Raymond M, Murphy WJ et al. (1999) The promise of comparative genomics in mammals. Science 286: 458–481.

Postlethwaite JH and Talbot WS (1997) Zebrafish genomics: from mutants to genes. Trends in Genetics 13: 183–190.

Rettenberger G, Klett C, Zechner U et al. (1995) ZOO‐FISH analysis: cat and human karyotypes closely resemble the putative ancestral mammalian karyotype. Chromosome Research 3: 479–486.

Wakefield MJ and Graves JAM (1996) Comparative mapping in vertebrates. Mammalian Genome 7: 715–716.

Further Reading

Ferguson‐Smith MA, Yang F and O'Brien PCM (1998) Comparative mapping using chromosome sorting and painting. ILAR Journal 39: 68–76.

First International Workshop on Comparative Genome Organization (1996) Comparative genome organization of vertebrates. Mammalian Genome 7: 717–734.

Nicholas FW and Harper PAW (1996) Inherited disorders: the comparative picture. Australian Veterinary Journal 73: 64–66.

O'Brien SJ (ed) (1993) Genetic Maps; Locus Maps of Complex Genomes, 6th edn. New York: Cold Spring Harbor Laboratory Press.

VandeBerg JL and Graves JAM (eds) (1998) Comparative mapping in mammals. ILAR Journal 39 special issue no. 2,3.

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Graves, Jennifer A Marshall(Apr 2001) Gene Mapping: Comparative. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001448]