X‐Chromosome Inactivation

Abstract

In female mammals, one of the X‐chromosomes is transcriptionally silenced by heterochromatin formation to bring about equal expression of X‐linked genes in XX females and XY males.

Keywords: X‐chromosome; inactivation; XIST; methylation; replication

References

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Further Reading

Brockdorff N and Duthie SM (1998) X‐chromosome inactivation and the Xist gene. Cellular and Molecular Life Sciences 54: 104–112.

Goto T and Monk M (1998) Regulation of X‐chromosome inactivation in development in mice and humans. Microbiology and Molecular Biology Reviews 62: 362–378.

Heard C, Clerc P and Avner P (1997) X‐chromosome inactivation in mammals. Annual Review of Genetics 31: 571–610.

Lyon MF (1961) Gene action in the X chromosome of the mouse. Nature 190: 372–373.

Panning B and Jaenisch R (1998) RNA and the epigenetic regulation of X chromosome inactivation. Cell 93: 305–308.

Spusta SC and Goldman MA (1999) XISTential wanderings: the role of XIST RNA in X‐chromosome inactivation. Current Science 77: 530–537.

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How to Cite close
Gartler, Stanley M, and Goldman, Michael A(May 2005) X‐Chromosome Inactivation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0004172]