Drosophila Embryo: Maternal Interactions in Specification of the Anterior–Posterior Axis

Abstract

In Drosophila, the anterior–posterior axis of the body plan is established during egg development by maternally expressed molecules.

Keywords: RNA localization; translational control; intercellular signalling; bicoid; nanos

Figure 1.

Stage 10 egg chamber expressing a Vas–green fluorescent protein (GFP) fusion protein. Vas accumulates in particles surrounding the nurse cell nuclei (ncn) and in the pole plasm (pp) at the posterior of the oocyte (oo). Photograph courtesy of S. Styhler, McGill University.

Figure 2.

Cuticle preparation of a bicaudal embryo, consisting of a mirror‐image duplication of posterior pattern elements and lacking anterior pattern elements. This embryo was produced by a Bic‐C mutant female, a mutation that results in premature unlocalized translation of osk.

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References

Bergsten SE and Gavis ER (1999) Role for mRNA localization in translational activation but not spatial restriction of nanos RNA. Development 126: 659–669.

Carrera P, Johnstone O, Nakamura A et al. (2000) VASA mediates translation through interaction with a Drosophila yIF2 homolog. Molecular Cell 5: 181–187.

Ephrussi A and Lehmann R (1992) Induction of germ cell formation by oskar. Nature 358: 387–392.

Ghabrial A and Schüpbach T (1999) Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis. Nature Cell Biology 1: 354–357.

Godt D and Tepass U (1998) Drosophila oocyte localization is mediated by differential cadherin‐based adhesion. Nature 395: 387–391.

González‐Reyes A and St Johnston D (1998) The Drosophila AP axis is polarised by the cadherin‐mediated positioning of the oocyte. Development 125: 3635–3644.

González‐Reyes A, Elliott H and St Johnston D (1995) Polarization of both major body axes in Drosophila by gurken‐torpedo signalling. Nature 375: 654–658.

Iida T and Kobayashi S (1998) Essential role of mitochondrially encoded large rRNA for germ line formation in Drosophila embryos. Proceedings of the National Academy of Sciences of the USA 95: 11274–11278.

Jiménez G, Guichet A, Ephrussi A and Casanova J (2000) Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes and Development 14: 224–231.

Schnorrer F, Bohmann K and Nüsslein‐Volhard C (2000) The molecular motor dynein is involved in targeting Swallow and bicoid RNA to the anterior pole of Drosophila oocytes. Nature Cell Biology 2: 185–190.

Shulman JM, Benton R and St Johnston D (2000) The Drosophila homolog of C. elegans PAR‐1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell 101: 377–388.

Xie T and Spradling AC (1998) decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94: 251–260.

Further Reading

Bashirullah A, Cooperstock RL and Lipshitz HD (1998) RNA localization in development. Annual Review of Biochemistry 67: 335–394.

de Cuevas M, Lilly MA and Spradling AC (1997) Germline cyst formation in Drosophila. Annual Review of Genetics 31: 405–428.

Eddy EM (1975) Germ plasm and the differentiation of the germ cell line. International Review of Cytology 43: 229–281.

Saffman EE and Lasko P (1999) Germline development in vertebrates and invertebrates. Cellular and Molecular Life Sciences 55: 1141–1163.

van Eeden F and St Johnston D (1999) The polarisation of the anterior–posterior and dorsal–ventral axes during Drosophila oogenesis. Current Opinion in Genetics and Development 9: 396–404.

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How to Cite close
Lasko, Paul(Mar 2003) Drosophila Embryo: Maternal Interactions in Specification of the Anterior–Posterior Axis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001503]