Repetitive DNA: Evolution


Repetitive DNA sequences form a substantial fraction of the genomes of most eukaryotes. Far from conferring fitness benefits to their host, in most cases repetitive sequences are maintained solely by their ability to replicate within the genome.

Keywords: tandem‐repetitive DNA; transposable elements; ‘selfish DNA’ hypothesis; mechanisms of copy‐number change; natural selection; copy‐number variation


Blattner FR, Plunkett G III, Block CA et al. (1997) The complete genome sequence of Escherichia coli K‐12. Science 277: 1453–1474.

Capy P, Bazin C, Higuet D and Langin T (1998) Dynamics and Evolution of Transposable Elements. Heidelberg, Germany: Springer.

Charlesworth B, Sniegowski P and Stephan W (1994) The evolutionary dynamics of repetitive DNA in eukaryotes. Nature 371: 215–220.

Csink AK and Henikoff S (1998) Something from nothing: the evolution and utility of satellite repeats. Trends in Genetics 14: 200–204.

Dib C, Faure S, Fizames C et al. (1996) A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature 380: 152–154.

Jeffreys AJ, Tarnaki K, MacLeod A et al. (1994) Complex gene conversion events in germline mutation at human minisatellites. Nature Genetics 6: 136–145.

John B and Miklos GLG (1988) The Eukaryote Genome in Development and Evolution. London: Allen and Unwin.

Levinson G and Gutman GA (1987) Slipped‐strand mispairing: a major mechanism for DNA sequence evolution. Molecular Biology and Evolution 4: 203–221.

Queller DC, Strassmann JE and Hughes CR (1993) Microsatellites and kinship. Trends in Ecology and Evolution 8: 285–288.

Stephan W (1997) Tandem‐repetitive noncoding DNA sequences. In: Meyers RA (ed.) The Encyclopedia of Molecular Biology and Molecular Medicine, vol. 6, pp. 1–10. Weinheim, Germany: Verlagsgesellschaft.

Further Reading

Alexandrov I, Kazakov A, Tumeneva I, Shepelev V and Yurov Y (2001) Alpha‐satellite DNA of primates: old and new families. Chromosoma 110: 253–266.

Berg DE and Howe MM (eds) (1989) Mobile DNA. Washington, DC: American Society for Microbiology.

Cavalier‐Smith T (ed.) (1985) The Evolution of Genome Size. Chichester, UK: Wiley.

Hedges DJ and Batzer MA (2005) From the margins of the genome: mobile elements shape primate evolution. Bioessays 27(August): 785–794.

Kidwell MG (2006) Transposable elements and the evolution of genome size in eukaryotes. Genetica 115: 49–63.

Li W‐H (1997) Molecular Evolution. Sunderland, MA: Sinauer.

Li YC, Korol AB, Fahima T and Nevo E (2004) Microsatellites within genes: structure, function, and evolution. Molecular Biology and Evolution 21: 991–1007.

Ugarkovic D (2005) Functional elements residing within satellite DNAs. EMBO Reports 6: 1035–1039.

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Stephan, Wolfgang, and Walsh, Bruce(Dec 2007) Repetitive DNA: Evolution. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0001700.pub2]